Ruzhilo O.S., Divakova T.S.
The influence of polymorphous gene variants of receptors activating proliferation of peroxisomas PPART and PPARGC1A on the development of polycystic ovary syndrome
Abstract. The objective of the present investigation was to study the contribution of polymorphism of the genes coding PPARe and PPARGC1A to the development of polycystic ovary syndrome (PCOS) in women of the reproductive age living in Belarus.
We investigated 120 women using the case-control study method. The main group included 60 women with polycystic ovary syndrome (PCOS), and the control group included 60 healthy women. Molecular-genetic research was conducted using PCR-RFLP analysis. PCOS patients more frequently than controls were carriers of alleles with reduced functional genes activity (PPARr (rs4253778): 33=12,87, OR 2,87 (95% CI 1,60-5,52), p<0,001; PPARGC1A (rs8192678): <<=19,1, OR 3,78 (95% CI 2,05-6,94), p<0,001).
Carriage of allele C of the gene PPARC and that of allele A of the gene PPARGC1A are considered as associated with PCOS.
Key words: polycystic ovary syndrome, genes PPARo and PPARGC1A, genetic polymorphism.