Kosinets V.A.
Pathogenetic aspects of complex treatment of patients with generalized purulent peritonitis
Abstract.
In this article the review of literature data and also the results of our own researches on the problem of treatment of patients with generalized peritonitis is presented. Despite the achievements of modern medicine, peritonitis still occupies one of the leading positions in regard to its relevance in abdominal surgery. Numerous pilot and clinical trials promoted the development of fundamental principles of this disease treatment which allowed to cease considering peritonitis outcome to be inevitably lethal. Nevertheless, according to modern literature data, the lethality in generalized purulent peritonitis widely ranges from 9,79 to 84% and averages 38,6-45% which, still, testifies to the lack of a uniform effective integrated approach to its treatment. In the article significant links of the disease and also possible ways of impact on them are considered. The attention is focused on the importance of studying the fundamental reasons of the development of pathological cascade changes in an organism in peritonitis and the necessity of complex application of multidirectional methods for the purpose of their elimination.
Key words: generalized purulent peritonitis, bioenergetic processes, amber acid, lipid-transport system, omega-3-fatty acids, immunotherapy, interleukin-2.
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