Pashko A.Y., Bushma K.M., Borisenok O.A., Bushma M.I.
Structural and functional disturbances in the liver of rats with cholestasis and their correction by means of the combination of taurine with zinc diaspartate
Education Establishment "Grodno State Medical University", Republic of Belarus
Abstract.
The purpose of the study is to evaluate the hepatoprotective properties of the combination of taurine with zinc diaspartate («taucin») in rats with cholestatic liver damage. In experiments on 24 mongrel male rats it has been shown that the common bile duct ligation within 13 days is accompanied by the appearance of areas of the liver parenchyma necrosis, porto-portal fibrosis, leukocyte infiltration and proliferation of cholangioles; inhibition in hepatocytes of SDH (succinate dehydrogenase) and LDH (lactate dehydrogenase); increase in the plasma activity of ALAT (alanine aminotransferase), AST (aspartate aminotransferase), GGT (s-glutamyltranspeptidase) and ALP (alkaline phosphatase), the content of total bilirubin and its fractions. «Taucin» (taurine - 50 g/mol; 6,25 g + zinc diaspartate - 1 g/mol; 0,35 g) introduced into the stomach in the dose of 0,5 g/kg/day during 11 days has hepatoprotective action. The structure of the liver improves (areas of necrosis are not revealed, the severity of porto-portal fibrosis and leukocyte infiltration reduces, the density of cholangioles increases), inhibited metabolic processes (SDH, LDH) in hepatocytes are activated, biochemical markers of hepatotoxicity in plasma improve (the activity of ALAT and AST, GGT and ALP, the content of total bilirubin and its fractions dicrease).
Key words: rats, cholestasis, «tauсin», hepatoprotective action.
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