Basalay O.N., Kravchuk R.I., Bushma К.M., Mikhalchuk E.Ch., Zimatkin S.M., Sheybak V.M.
Cytoprotective effect of taucine in rats with the damage of nephron glomeruli with corrosive sublimate
Education Establishment "Grodno State Medical University", Republic of Belarus
Abstract.
The aim of this investigation was to study the cytoprotective action of the combination of taurine with zinc diaspartate (taucine) on the damaged with corrosive sublimate glomeruli of nephrons in rats. The experiments have been conducted on 42 mongrel male rats. Sublimate was administered intraperitoneally in a dose of 0,1 mg/kg/day during 14 days. Taucine (20 g/mole of taurine – 2,5 g and 1 g/mole of zinc diaspartate – 0,35 g) was introduced into the stomach in the form of a solution of macromolecules in starch in a dose of 500 mg/kg simultaneously with sublimate once a day. Cytoprotective action of taucine concerning podocytic cells of renal corpuscles in cortical nephrons (CN) has been revealed. It increases the lowered volume of capsular cavity (by 50%), the quantity of cytopodia (by 25%) and decreases the increased intrapeduncular spaces (by 50%), thickness of basal membrane (by 22%). As a result the function of the kidney improves judging by the increase in the secretion of urea (by 38%), creatinine (by 32%), clearance of creatinine (by 56%); polyuria manifestations decrease. In the mechanism of this cytoprotective action of taucine the binding properties of taurine concerning sublimate play their role, promoting its excretion. It is an intracellular osmoregulator and an antioxidant. Zinc as a cofactor is a component of more than 200 enzymes of the intracellular metabolism disturbed with sublimate, including superoxiddismutase, which neutralizes cytotoxic superoxid-anion.
Key words: rats; damage of nephrons glomeruli with sublimate, combination of taurine with zinc diaspartate, cytoprotective action.
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