Katina E.L.*, Konorev M.R.*, Bukhtarevich S.P.**
Comparative analysis of the effectiveness of perioperative antisecretory pharmacotherapy schemes on polypectomy of the stomach and duodenum
*Education Establishment "Vitebsk State Order of Peoples’ Friendship Medical University", Republic of Belarus
**Public Health Establishment "Vitebsk Regional Clinical Specialized Centre", Republic of Belarus
Abstract.
The purpose of this research was to make a comparative analysis of the effectiveness of three perioperative antisecretory pharmacotherapy regimens in patients with polyps of the stomach and duodenum. 61 patients were included into the study, among them 59 persons with gastric polyps and 2 persons with duodenal polyps, who were randomized into three parallel groups. Patients of the first group received 20 mg of omeprazole 2 times a day, starting with the day preceding endoscopic polypectomy (EPE), patients of the second group – beginning with the day when EPE was performed and the third group of patients - beginning with the day following the removal of the polyp. In all patients electroexcision of polyps was conducted by means of diathermy loop. In each group the control endoscopic examinations were done on the next day and on the fifth day after polypectomy. To evaluate the effectiveness of pharmacotherapy, the changes in the size of postcoagulation defect were estimated, and its macroscopic characteristics were evaluated as well. We have also made pharmacoeconomic analysis of the proposed schemes of pharmacotherapy. According to the obtained data, in the first and in the second groups of patients the healing of the mucosa defect occurred significantly faster than in the third group (P1-3<0,017), (P2-3<0,017), (P1-2>0,017). It was found that the pure (white) base of postcoagulation defect on the next day after EPE was observed more frequently in the first and in the second groups of patients in comparison with the third one (P1-3<0,017), (P2-3<0,017), (P1-2>0,017). As a result of the conducted study, it was determined that the scheme which includes 20 mg of omeprazole twice a day administered immediately on the day of endoscopic polypectomy is an effective and less expensive regimen of antisecretory pharmacotherapy, contributing to the increased rate of postcoagulation mucosal defect healing.
Key words: polyp, stomach, duodenum, рroton рump inhibitors.
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