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Vykhristenko K.S., Smirnova O.V.
Clinical and laboratory efficacy of intraoperative hemocarboperfusion during extracorporeal circulation
Education Establishment "Vitebsk State Order of Peoples’ Friendship Medical University", Republic of Belarus

Abstract.
Objectives. To evaluate clinical and laboratory efficacy as well as safety of intraoperative hemocarboperfusion during extracorporeal circulation (cardiopulmonary bypass) in cardiosurgical patients.
Material and methods. The study involved 32 patients with heart diseases who underwent cardiac surgery with cardiopulmonary bypass, equally divided into two groups,  one group was treated with the application of hemocarboperfusion.   To assess the systemic inflammatory response to surgical trauma we used MODS (Multiple Organ Dysfunction Score) scale, reflecting the severity of multiple organ dysfunction and the severity of the patient's condition, the amount of postoperative blood loss, the presence of the postcardiotomy syndrome, the occurrence of postoperative infectious complications were also taken into account.
Results. We found reliable differences according to MODS scale between the groups, which allow to predict a lower mortality rate in patients, operated with the use of hemocarboperfusion. A lower incidence of the postcardiotomy syndrome development was revealed in the group with hemocarboperfusion application. Adverse reactions to hemocarboperfusion in the examined patients were not observed.
Conclusions. The application of hemocarboperfusion in the intraoperative period during extracorporeal circulation reduces the severity of systemic inflammatory response syndrome and the number of complications in patients undergoing cardiac surgery.
Key words: efficacy, safety, hemocarboperfusion, extracorporeal circulation.

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