V.P. Podpalov, N.S. Balashenko
Cardiovascular system remodelling and biochemical parameters in patients with arterial hypertension of the 1st-2nd degree combined with atherosclerotic lesion of carotid arteries
Educational Establishment «Vitebsk State Order of Peoples’ Friendship Medical University», Vitebsk, Republic of Belarus
Abstract.
Objectives. To study the cardiovascular system remodelling and biochemical parameters in patients with hypertension (HT) of the 1st-2nd degree in association with atherosclerotic lesion of carotid arteries.
Material and methods. 265 patients (190 persons with HT of the 1st-2nd degree and 75 practically healthy subjects) were examined. 120 patients with HT of the 1st-2nd degree had atherosclerotic plaques in their carotid arteries. The data from the standard questionnaire, office BP measurement, ambulatory blood pressure monitoring, electrocardiography (ECG), Holter ECG monitoring, echocardiography, carotid arteries ultrasound investigation, pulse wave velocity definition, biochemical serum and urine data (lipid parameters, C-reactive protein, glucose, creatinine and microalbumin) were evaluated.
Results. Patients with HT of the 1st-2nd degree in association with carotid atherosclerotic plaques had more expressed changes in the heart and vessels remodelling processes which were determined according to the results of echocardiography, Holter ECG monitoring, ultrasound investigation of the carotid arteries. It was also found that patients with HT of the 1st-2nd degree in association with carotid atherosclerotic plaques had more expressed changes in biochemical parameters of blood serum in the form of higher levels of total cholesterol, triglycerides, low density lipoprotein cholesterol, C-reactive protein compared with the group of patients with HT of the 1st-2nd degree without atherosclerotic plaques in their carotid arteries.
Key words: arterial hypertension, remodelling, cardiovascular system, atherosclerotic plaques of carotid arteries.
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