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Gorodetskaya I.V., Masyuk N.Y.
The influence of iodine-containing thyroid hormones on the resistance of the enamel and dentin to caries, stress and their combination
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus

Vestnik VGMU. 2017;16(1):23-32.

Objectives. To study the effect of iodine-containing thyroid hormones on the resistance of the enamel and dentin to the carious lesion under stress.
Material and methods. The experiments were performed on 390 mongrel male rats maintained on the cariogenic diet of Stefan, under the conditions of crowding stress (40 animals were in one cage during the first 30 days, 30 animals-during the next 30 days) and under those of the combination of both influences. Hypothyroidism was caused by the intragastric administration of mercazolil in 1% starch paste in the dose of 25 mg / kg during 30 days, and then in the half dose till the end of the experiment. L-thyroxin was injected in the similar way in the increasing doses from 1,5 to 3,0 mcg / kg during 28 days, then in the dose of 1,5 mcg / kg till the 60th day. The general resistance of an organism was characterized by a change of the relative weight of stress-sensitive organs, the state of the gastric mucosa. The activity of the caries process was evaluated by its prevalence, frequency, severity and depth.
Results. It has been found that experimental hypothyroidism reduces the body’s resistance to stress and exacerbates the caries process in animals kept in congested conditions, on the cariogenic diet and under the conditions of these influences combination. The small doses of L-thyroxin stimulate the adaptive capacities of the body, limit the intensity of dental caries caused by the use of the cariogenic diet, isolated and combined with the congested keeping of rats, and prevent its development under stress.
Conclusions. Therefore, the resistance of dental hard tissues to the cariogenic impact depends on the thyroid status of the organism, which proves the necessity for its studying and correction in patients with the high activity of the caries process and in persons subject to frequent stress influences.
Key words: iodine-containing thyroid hormones, stress, caries resistance.


1. Sheiham A, James WP. Diet and dental caries: the pivotal role of free sugars reemphasized. J Dent Res. 2015 Oct;94(10):1341-7. doi:
2. Yudina NA. Justification of pathogenetic mechanisms of interrelation of stomatologic and general diseases. Stomatol Zhurn. 2004;(2):16-9. (In Russ.)
3. Demidchik YuE, Lutskaya IK, Dem'yanenko EA. Influence studying a stress factors on an organism in an experiment. Vestsі NAN Belarusі Ser Med Navuk. 2013;(4):46-50. (In Russ.)
4. Gorodetskaya IV, Evdokimova OV. Influence of iodinated thyroid hormones on an expression of early genes c-fos and c-jun in a myocardium of rats at a stress. Vestsі NAN Belarusі Ser Med Navuk. 2014;(2):42-7. (In Russ.)
5. Gorodetskaya IV, Gusakova EA. The influence of thyroid status on the system of proteolysis under stress. Ros Fiziol Zhurn im IM Sechenova. 2013;99(12):1378-88. (In Russ.)
6. Pavlova TV, Peshkova EK, Kolesnikov DA. Clinical observations and the analysis of the stomatologic status of patients with diseases of a thyroid gland. Fundam Issled. 2012;(4-1):97-100. (In Russ.)
7. Stephan RM, Harris NR. Location of experimental carles on different tooth surfaces in the Norway rat. In: Sognnaes RF, editor. Advances in Experimental Caries Research. Washington; 1955. р. 47-65.
8. Kirillov NA, Smorodchenko AT. The histochemical characteristic of structures of lymphoid organs of rats under the influence of a stress. Biul Eksperiment Biologii Meditsiny. 1999;127(2):171-3. (In Russ.)
9. Volozhin AI, Tarasenko LM, Neporada KS, Skrypnik IN. Experimental model of a round ulcer of a stomach. Patol Fiziol Eksperim Terapiia. 2001;(4):27-8. (In Russ.)
10. Donskiy GI, Pavlyuchenko ON, Melikov AV; Donets gos med un-t im M Gor'kogo. Way of modeling of caries. Pat № 4781223/14 SU 1720082 SSSR, G 09 B 23/28. 1992 Mar 15. Biul;(10). (In Russ.)
11. Gorodetskaya IV, Korenevskaya NA. Dependence of changes of lipid peroxidation and antioxidant activity in acute and chronic stress from thyroid status of the organism. Patol Fiziologiia Eksperim Terapiia. 2010;(4):38-42. (In Russ.)
12. Gulenko AV, Khagurova SB, Volobuev VV. Indicators of antioxidatic protection of stomatic liquid at caries of teeth at children with psychoneurological disorders. Mezhdunar Zhurn Prikladnykh Fundam Issled. 2014;(2):64-8.
13. Lee TY, Jin EJ, Choi B. MMP-13 expression in coronal and radicular dentin according to caries progression – a pilot study. Tiss Eng Reg Med. 2013;10(6):317-21. doi:
14. Gorodetskaya IV, Bozhko AP, Bakhtina LYu, Malyshev IYu. The importance of thyroid hormones in stressinducing the synthesis of heat shock proteins in myocardium. Biul Eksperim Biologii Meditsiny. 2000;130(12):617-9. (In Russ.)

Information about authors:

Gorodetskaya I.V. – Doctor of Medical Sciences, professor of the Chair of Normal Physiology, Vitebsk State Order of Peoples’ Friendship Medical University;
Masyuk N.Y. – postgraduate of the Chair of Normal Physiology, Vitebsk State Order of Peoples’ Friendship Medical University.

Correspondence address: Republic of Belarus, 210023, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Normal Physiology. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Irina V. Gorodetskaya.

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