DOI: https://doi.org/10.22263/2312-4156.2017.2.91
Melnik-Sheremeta O.P., Ostrovsky N.N.
The influence of glucosaminilmuramilpentapeptide on the pathogenetic links of the processes of neocollagenesis and bronchial tree inflammation in infiltrative tuberculosis of the lungs accompanied by chronic bronchitis
Ivano-Frankovsk National Medical University, Ivano-Frankovsk, Ukraine
Vestnik VGMU. 2017;16(2):91-96.
Abstract.
The peculiarities of neocollagenesis and local inflammation of the bronchial tree in patients with infiltrative tuberculosis combined with chronic bronchitis, who in addition to the main course of treatment received the immunomodulator of muramilpeptide series are presented in this article. The study involved 40 patients with infiltrative tuberculosis combined with chronic bronchitis. Formulation of the diagnosis of infiltrative tuberculosis was made according to the materials of the order of the Ukrainian Ministry of Health dated of 16.08.2013 № 731 and № 620 dated of 09.04.2014 «On approval of the unified clinical protocol of primary, secondary (specialized) and tertiary (highly specialized) medical aid in case of tuberculosis». The diagnosis of chronic bronchitis was made on the basis of the International Statistical Classification of Diseases and Health Problems X, clinical, physical and instrumental signs (productive cough for at least 3 months a year during 2 or more years, the presence at the exacerbation stage of dry rales, anamnestic exacerbations 2-3 per year over the last 2 years, such radiological signs as thickening of the bronchial walls, and pneumosclerosis). The evaluation of type IV collagen and C-reactive protein level in the bronchoalveolar contents was conducted before the beginning, on the 30th and on the 150th day of TB treatment using the standard scheme according to the first category with the administration of glucosaminilmuramilpentapeptide. Having assessed the results of the study, we noticed a significant decrease in the indices of type IV collagen and C-reactive protein in the main group compared to the group in which the patients received only the standard treatment.
Key words: tuberculosis, chronic bronchitis, type IV collagen, C-reactive protein.
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Information about authors:
Melnik-Sheremeta O.P. – Master of Medical Sciences, teacher of the Chair of Phthisiology and Pulmonology with the course of Occupational Diseases, Ivano-Frankovsk National Medical University, Ukraine;
Ostrovsky N.N. – Doctor of Medical Sciences, professor, head of the Chair of Phthisiology and Pulmonology with the course of Occupational Diseases, Ivano-Frankovsk National Medical University, Ukraine.
Correspondence address: Ukraine, 76010, Ivano-Frankovsk, 42 Pivdenny Bulvar str., 110. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Olga P. Melnik-Sheremeta.
