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Chekalina N.I., Manusha Y.I.
The expediency substantiation of the resveratrol and quercetin polyphenols use in ischemic heart disease combined with autoimmune thyroiditis. Part I
Ukrainian Medical Stomatological Academy, Poltava, Ukraine

Vestnik VGMU. 2017;16(5):40-48.

This review presents modern scientific conceptions concerning the mechanisms of the formation and progression of atherosclerosis - the morphological basis of coronary heart disease (CHD) - and autoimmune thyroiditis in terms of the inflammatory theory, recognized as the leading one in the pathogenesis of the above diseases. The inflammatory mechanisms realized at the epigenetic, molecular, cellular levels, their community and universality in the development of both pathologies are described. The role of polyphenolic compounds as powerful anti-inflammatory agents is shown.
The main mechanisms of anti-inflammatory activity of resveratrol and quercetin are specified, which proves the expediency of their use in the complex treatment of diseases, in the development of which the leading role is played by chronic systemic inflammation.
Key words: ischemic heart disease, atherosclerosis, autoimmune thyroiditis, chronic systemic inflammation, resveratrol, quercetin.


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Information about authors:
Chekalina N.I. – Candidate of Medical Sciences, associate professor of the Chair of Propedeutics of Internal Medicine with Patients Care, General Practice (Family Medicine), Ukrainian Medical Stomatological Academy;
Manusha Y.I. – postgraduate of the Chair of Internal Medicine with Patients Care, General Practice (Family Medicine), Ukrainian Medical Stomatological Academy.

Correspondence address: Ukraine, 36000, Poltava, 23 Shevchenko str., Ukrainian Medical Stomatological Academy, Chair of Propedeutics of Internal Medicine with Patients Care, General Practice (Family Medicine). E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Natalya I. Chekalina.

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