Torianik I.I.1,2,3, Pokhil S.I.1, Timchenko Ye.N.1, Danilchenko S.I.4, Chigirinskaya N.А.1, Kostyria I.А.1
Morphological characteristic of the mucous membrane and lymphoid structures of the appendix in cryptosporidiosis against the background of HIV/AIDS infection
1I.I. Mechnikov Institute of Microbiology and Immunology of the National Academy of Medical Sciences of Ukraine, Kharkov, Ukraine
2Kharkov National Medical University, Kharkov, Ukraine
3Kharkov Medical Academy of Post-Graduate Education, Kharkov, Ukraine
4Petro Mohyla Black Sea National University, Nikolaev, Ukraine
Vestnik VGMU. 2017;16(5):90-95.
Cryptosporidiosis is natural focal anthropozoonosis. This is a relatively new parasitic infection with an acute or subacute course, characterized by the lesion of mucous membranes of the gastrointestinal tract organs and diarrhea. Cryptosporidiosis becomes dangerous for people in the conditions of marked immunodepression occurrence and prolonged chronization of infection complications, that contribute to its accelerated development. As a rather new infection (some researchers qualify it as an emergent one) human cryptosporidiosis is characterized by poor pathomorphological data and almost unknown lethality (in a number of cases the cause of death is considered to be either the main or concomitant disease). But under the favourable conditions for the development of a mixed infection the consequences of this disease can be extremely unpredictable. With the last fact taken into account the study of morphological changes in cryptosporidiosis (first of all, in mucous membranes of the gastrointestinal tract organs) is opportune. In the present research we studied the biological material (fragments of the mucous membrane of the appendix and its lymphoid formations) from a patient, who died as a result of the development of acute gastroenteric syndrome against the background of HIV/AIDS and cryptosporidiosis. The final diagnosis was based on the results of complex clinical-anamnestic, laboratory, pathomorphological studies with resultant revealing of signs characteristic of an inflammatory process, which manifested itself by the appearance of the swollen mucous membrane, its exhaustion and sometimes atrophy. In the submucous base of the antral compartment infiltrates with macrophages, neutrophilic and eosinophilic leukocytes were revealed. Its opening contained mucus with the erythrocytes admixture. Summarizing the above facts it should be pointed out that the manifestation of the infectious process with typical clinical-morphological signs of cryptosporidiosis was caused by its course against the background of HIV/AIDS infection.
Key words: appendix, mucous membrane, lymphoid structures, cryptosporidiosis, HIV/AIDS infection, morphology.
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Information about authors:
Torianik I.I. – Candidate of Medical Sciences, leading research officer of the Laboratory of Viral Infections, I.I. Mechnikov Institute of Microbiology and Immunology of the National Academy of Medical Sciences of Ukraine; associate professor of the Chair of Economics & Management in Family Medicine, Kharkov Medical Academy of Post-Graduate Education; leading research officer of the Central Scientific-Research Laboratory, Kharkov National Medical University;
Pokhil S.I. – Doctor of Medical Sciences, head of the Laboratory of New and Insufficiently Known Infectious Diseases, I.I. Mechnikov Institute of Microbiology and Immunology of the National Academy of Medical Sciences of Ukraine;
Timchenko Ye.N. – Candidate of Medical Sciences, leading research officer of the Laboratory of New and Insufficiently Known Infectious Diseases, I.I. Mechnikov Institute of Microbiology and Immunology of the National Academy of Medical Sciences of Ukraine;
Danilchenko S.I. – Candidate of Medical Sciences, associate professor of the Chair of Olympic & Professional Sport, Petro Mohyla Black Sea National University;
Chigirinskaya N.A. – senior research officer of the Laboratory of New and Insufficiently Known Infectious Diseases, I.I. Mechnikov Institute of Microbiology and Immunology of the National Academy of Medical Sciences of Ukraine;
Kostyria I.A. – research officer of the Laboratory of New and Insufficiently Known Infectious Diseases, I.I. Mechnikov Institute of Microbiology and Immunology of the National Academy of Medical Sciences of Ukraine.