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Gorodetskaya I.V., Masyuk N.Yu.
The effect of iodine-containing thyroid hormones on the tissues of the maxillofacial area
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus

Vestnik VGMU. 2018;17(2):20-29.

The change in the level of iodine-containing thyroid hormones results in a number of negative consequences in the body, including the damage to the maxillofacial area tissues. The main dental manifestations of the thyroid dysfunction, i.e. disruption in the formation and eruption of temporary and permanent teeth, their carious lesion, inflammatory and degenerative processes in the periodontium and gums, destruction of the alveolar bones of the jaws have been studied and summarized. The review deals with the analysis of those factors that reduce the resistance of the oral cavity tissues, as well as the determination of their alteration mechanisms (stimulation of lipid peroxidation and proteolysis, depression of the activity of antioxidant systems, decrease in the rate of salivation, disturbance of the ionic composition of the saliva, the ratio between the activity of acidic and alkaline phosphatases in it, suppression of the local immunity, damaged microcirculation in the dental pulp). Special attention is paid to establishing the possibility of increasing the resistance of the enamel, dentin and their surrounding tissues to stress by means of the purposeful correction of the thyroid status.
Key words: hypothyroidism, hyperthyroidism, caries, saliva.


1. Feitosa DS, Marques MR, Casati MZ, Sallum EA, Nociti FH, de Toledo S. The influence of thyroid hormones on periodontitis-related bone loss and tooth-suppording alveolar bone: a histological study in rats. J Periodontal Res. 2009 Aug;44(4):472-8. doi:
2. Seifi M, Hamedi R, Khavandegar Z. The Effect of Thyroid Hormone, Prostaglandin E2, and Calcium Gluconate on Orthodontic Tooth Movement and Root Resorption in Rats. J Dent (Shiraz). 2015 Mar;16(1 Suppl):35-42.
3. Kim JC, Lee YH, Yu MK, Lee NH, Park JD, Bhattarai G, et al. Anti-inflammatory mechanism of PPARγ on LPS-induced pulp cells: role of the ROS removal activity. Arch Oral Biol. 2012 Apr;57(4):392-400. doi:
4. Artemenko TV, Sakharuk NA. Analysis of dental health in patients with endocrine pathology (hypothyroidism). Vestn VGMU. 2014;13(2):124-8. (In Russ.)
5. Beriashvili S, Nikolaishvili M, Mantskava M, Momtsemlidze N, Franchuk K. Changes in tooth hard tissue mineralization and blood rheology in healthy adolescents and those with thyroid dysfunction. Georgian Med News. 2016 Nov;(Issue):28-34.
6. Asiyatilov AKh, Asiyatilov GA, Ordashev KhA. State of the salivary system in patients with sialadenosis in thyroid pathology. Vestn Dagestan Gos Med Akad. 2012;(1):28-30. (In Russ.)
7. Falcão DP, da Mota LM, Pires AL, Bezerra AC. Sialometry: aspects of clinical interestю Rev Bras Reumatol. 2013 Nov-Dec;53(6):525-31.
8. Beriashvili SD, Mantskava M, Momtselidze NG, Tupinashvili TN, Nikolaishvuli MI, Tamasidze NA. Hemorhoelogical status during periodontitis with and without thyroid dysfunction between children the age of 11-15. Evraz Soiuz Uchenykh. 2015;(1-1):46-8.
9. Erem C, Suleyman AK, Civan N, Mentese A, Nuhoglu İ, Uzun A, et al. The effect of L-thyroxine replacement therapy on ischemia-modified albümin and malondialdehyde levels in patients with overt and subclinical hypothyroidism. Endocr Res. 2016 Nov;41(4):350-360. doi:
10. Cheserek MJ, Wu GR, Ntazinda A, Shi YH, Shen LY, Le GW. Association Between Thyroid Hormones, Lipids and Oxidative Stress Markers in Subclinical Hypothyroidism. J Med Biochem. 2015 Jul;34(3):323-331. doi:
11. Zha K, Zuo C, Wang A, Zhang B, Zhang Y, Wang B, et al. LDL in patients with subclinical hypothyroidism shows increased lipidperoxidation. Lipids Health Dis. 2015 Aug;14:95. doi:
12. Mayboroda YuN, Goman MV, Khorev OYu. Effect of Mexidol on lipid peroxidation and antioxidant activity of saliva in patients with periodontitis on the background of hypothyroidism. Kuban Nauch Med Vestn. 2014;(4):74-8. (In Russ.)
13. Baltaci AK, Mogulkoc R, Ayyildiz M, Kafali E, Koyuncuoglu T. Lipid peroxidation in kidney and testis tissues in experimental hypothyroidism: the role of zinc. Bratisl Lek Listy. 2014;115(8):498-501.
14. Jena S. Effect of persistent and transient hypothyroidism on histoarchitecture and antioxidant defence system in rat brain. Neurol Sci. 2015 Jun;36(6):953-9. doi:
15. Gorodetskaya IV, Korenevskaya NA. Influence of thyroid function on the reaction of tooth and periodontal tissues to stress. Stomatologiia. 2010;89(6):34-6. (In Russ.)
16. Erem C, Suleyman AK, Civan N, Mentese A, Nuhoglu İ, Uzun A, et al. Ischemia-modified albümin and malondialdehyde levels in patients with overt and subclinical hyperthyroidism: effects of treatment on oxidative stress. Endocr J. 2015;62(6):493-501. doi:
17. Cetinkaya A, Kurutas EB, Buyukbese MA, Kantarceken B, Bulbulogl E. Levels of malondialdehyde and superoxide dismutase in subclinical hyperthyroidism. Mediators Inflamm. 2005;(1):57-9. doi:
18. Rybus-Kalinowska B, Zwirska-Korczala K, Kalinowski M, Kukla M, Birkner E, Jochem J. Activity of antioxidative enzymes and concentration of malondialdehyde as oxidative status markers in women with non-autoimmunological subclinical hyperthyroidism. Endokrynol Pol. 2009 May-Jun;60(3):199-202.
19. Kong L, Wei Q, Fedail JS, Shi F, Nagaoka K, Watanabe G. Effects of thyroid hormones on the antioxidative status in the uterus of young adult rats. J Reprod Dev. 2015;61(3):219-27. doi:
20. Yücel R, Ozdemir S, Darıyerli N, Toplan S, Akyolcu MC, Yiğit G. Erythrocyte osmotic fragility and lipid peroxidation in experimental hyperthyroidism. Endocrine. 2009 Dec;36(3):498-502. doi:
21. Remenyakina EI, Pavlyuchenko II, Okhremenko OS, Panasenkova YuS. Comparative analysis of the state of Pro/antioxidant protection in patients with thyroid dysfunction of various origins. Sovrem Problemy Nauki Obrazovaniia. 2014;(2):335-6. (In Russ.)
22. Gorodetskaya IV, Evdokimova OV. Dependence on the state of lipid peroxidation and antioxidant system in the myocardium under short-term stress from thyroid status. Ros Fiziol Zhurn im IM Sechenova. 2013;99(11):1285-93. (In Russ.)
23. Gorodetskaya IV, Korenevskaya NA. Dependence of changes in lipid peroxidation and antioxidant activity in acute and chronic stress on the thyroid status of the body. Patol Fiziologiia Eksperim Terapiia. 2010;(4):38-42. (In Rus.)
24. Jena S, Bhanja S. Hypothyroidism alters antioxidant defence system in rat brainstem during postnatal development and adulthood. Neurol Sci. 2014 Aug;35(8):1269-74. doi:
25. Lobyreva OV, Abdullina GM, Kamilov FKh. Activity of antioxidant enzymes of rat liver in experimental hypothyroidism and its correction with iodine-containing polysaccharide complex. Om Nauch Vestn. 2011;104(1):92-4. (In Russ.)
26. Sinha RA, Pathak A, Kumar A, Tiwari M, Shrivastava A, Godbole MM. Enhanced neuronal loss under perinatal hypothyroidism involves impaired neurotrophic signaling and increased proteolysis of p75(NTR). Mol Cell Neurosci. 2009 Mar;40(3):354-64. doi:
27. Gorodetskaya IV, Gusakova EA. The role of iodine-containing thyroid hormones in the regulation of proteolysis system under stress in rats. Vestsі NAN Belarusі Ser Med Navuk. 2013;(4):65-70. (In Russ.)
28. Pancotto TE, Rossmeisl JH, Huckleb WR, Inzanaa KD, Zimmerman KL. Evaluation of endothelin-1 and MMPs-2, -9, -14 in cerebrospinal fluid as indirect indicators of blood-brain barrier dysfunction in chronic canine hypothyroidism. Res Vet Sci. 2016 Apr;(105):115-20. doi:
29. Riis AL, Jørgensen JO, Ivarsen P, Frystyk J, Weeke J, Møller N. Increased protein turnover and proteolysis is an early and primary feature of short-term experimental hyperthyroidism in healthy women. J Clin Endocrinol Metab. 2008 Oct;93(10):3999-4005. doi:
30. Muralidharan D, Fareed N, Pradeep PV, Margabandhu S, Ramalingam K, Ajith Kumar BV. Qualitative and quantitative changes in saliva among patients with thyroid dysfunction prior to and following the treatment of the dysfunction. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 May;115(5):617-23. doi:
31. Smidt D, Torpet LA, Nauntofte B, Heegaard KM, Pedersen AM. Associations between oral and ocular dryness, labial and whole salivary flow rates, systemic diseases and medications in a sample of older people. Community Dent Oral Epidemiol. 2011 Jun;39(3):276-88. doi:
32. de Jesus VC, Beanes G, Paraguassú GM, Ramalho LM, Pinheiro AL, Ramalho MJ, et al. Influence of laser photobiomodulation (GaAlAs) on salivary flow rate and histomorphometry of the submandibular glands of hypothyroid rats. Lasers Med Sci. 2015 May;30(4):1275-80. doi:
33. Sridevi D, Dambal AA, Sidrah, Challa AS, Padaki SK. A study of serum magnesium, calcium and phosphorus in hypothyroidism. Int J Clin Biochem Res. 2016;3(2):236-9.
34. Yu YR, Fallon SC, Carpenter JL, Athanassaki I, Brandt ML, Wesson DE, et al. Perioperative determinants of transient hypocalcemia after pediatric total thyroidectomy. J Pediatr Surg. 2017 May;52(5):684-688. doi:
35. Chen K, Xie Y, Zhao L, Mo Z. Hyperthyroidism-associated hypercalcemic crisis: A case report and review of the literature. Medicine (Baltimore). 2017 Jan;96(4):e6017. doi:
36. Liu J, Tang X, Cheng J, Yang X, Wang Y. Persistent arthralgia, vomiting and hypercalcemia as the initial manifestations of hyperthyroidism: A case report. Mol Clin Oncol. 2017 Feb;6(2):258-60. doi:
37. Strukov VI, Maksimova MN, Radchenko LG, Kuptsova TA. Rickets in children of the first year of life with transient thyroid insufficiency. Izv VUZo. Povolzh Region Med Nauki. 2013;(3):62-72. (In Russ.)
38. Yukhnovets AA. Cytochemical parameters of peripheral blood leukocytes in diseases of the thyroid gland. Vestn VGMU. 2003;2(3):71-8. (In Russ.)
39. El Hadidy el HM, Ghonaim M, El Gawad SSh, El Atta MA. Impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men. BMC Endocr Disord. 2011 Aug;11:15. doi:
40. Dutta D, Ahuja A, Selvan C. Immunoglobulin G4 related thyroid disorders: Diagnostic challenges and clinical outcomes. Endokrynol Pol. 2016;67(5):520-524. doi:
41. Konca Degertekin C, Aktas Yilmaz B, Balos Toruner F, Kalkanci A, Turhan Iyidir O, Fidan I, et al. Circulating Th17 cytokine levels are altered in Hashimoto’s thyroiditis. Cytokine. 2016 Apr;80:13-7. doi:
42. Yang H, Cong Y, Wu T, Tang H, Ma M, Zeng J, et al. Clinical efficacy of Yingliu mixture combined with metimazole for treating diffuse goitre with hyperthyroidism and its impact on related cytokines. Pharm Biol. 2017 Dec;55(1):258-263. doi:
43. Mihor A, Gergar M, Gaberšček S, Lenasi H. Skin microvascular reactivity in patients with hypothyroidism. Clin Hemorheol Microcirc. 2016 Nov;64(1):105-114. doi:
44. Scardina GA, Messina P. Modifications of interdental papilla microcirculation: a possible cause of periodontal disease in Hashimoto’s thyroiditis? Ann Anat. 2008;190(3):258-63. doi:
45. Bajuk NB, Zaletel K, Gaberšček S, Lenasi H. Hyperthyroidism induced by Graves’ disease reversibly affects skin microvascular reactivity. Clin Hemorheol Microcirc. 2015;61(3):459-70. doi:
46. Freitas F, Estato V, Carvalho VF, Torres RC, Lessa MA, Tibiriçá E. Cardiac microvascular rarefaction in hyperthyroidism-induced left ventricle dysfunction. Microcirculation. 2013 Oct;20(7):590-8. doi:
47. Marfella R, Ferraraccio F, Rizzo MR, Portoghese M, Barbieri M, Basilio C, et al. Innate immune activity in plaque of patients with untreated and L-thyroxine-treated subclinical hypothyroidism. J Clin Endocrinol Metab. 2011 Apr;96(4):1015-20. doi:
48. Guo Y, Wan SY, Zhong X, Zhong MK, Pan TR. Levothyroxine replacement therapy with vitamin E supplementation prevents the oxidative stress and apoptosis in hippocampus of hypothyroid rats. Neuro Endocrinol Lett. 2014;35(8):684-90.
49. Cray JJ Jr, Khaksarfard K, Weinberg SM, Elsalanty M, Yu JC. Effects of thyroxine exposure on osteogenesis in mouse calvarial pre-osteoblasts. PLoS One. 2013 Jul;8(7):e69067. doi:
50. Poumpros E, Loberg E, Engström C. Thyroid function and root resorption. Angle Orthod. 1994;64(5):389-93. doi:<0389:TFARR>2.0.CO;2

Information about authors:
Gorodetskaya I.V. – Doctor of Medical Sciences, professor of the Chair of Normal Physiology, dean of the Medical Faculty, Vitebsk State Order of Peoples’ Friendship Medical University;
Masyuk N.Yu. – postgraduate of the Chair of Normal Physiology, Vitebsk State Order of Peoples’ Friendship Medical University.

Correspondence address: Republic of Belarus, 210023, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Normal Physiology. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Natalya Yu. Masyuk.

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