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DOI: https://doi.org/10.22263/2312-4156.2020.5.17

Zavodnik L.B.1, Khokha R.N.2, Khokha A.M.3
Sensibilization to the allergens of domestic dust mites in children. Part 1
1Grodno State University named after Yanka Kupala, Grodno, Republic of Belarus
2Grodno State Medical University, Grodno, Republic of Belarus
3Grodno State Agrarian University, Grodno, Republic of Belarus

Vestnik VGMU. 2020;19(5):17-26.

Abstract.
Allergic diseases are a serious problem in modern medicine. Sensitization to inhalation allergens is one of the key factors in the formation of respiratory allergoses. Among aeroallergens, allergenic components of domestic dust play an important role – mites Dermatophagoides pteronyssinus and Dermatophagoides farinae, that make up to 90% of the acarofauna of residential premises. In the formation of sensitization to domestic dust mites, the role of individual sources of allergens is also considered. Sensitization to the major components of the domestic dust mite allergens is associated with the risk of developing bronchial asthma, to minor ones (Der p 10) – the risk of cross-reactions with tropomyosin of other invertebrates, human tropomyosin. Domestic dust mite allergens (Der p 2 and Der f 2) may be responsible for the symptoms of oral tick-born anaphylaxis as well as for the development of sensitization to bacterial antigens of Staphylococcus aureus and Escherichia coli.
Part 1 of this article outlines biology and sources of the domestic dust mite. The classification of allergens, sensitization pathways and the prevalence of sensitization to domestic dust mite in children are presented.
Key words: children, Dermatophagoides pteronyssinus, Dermatophagoides farinae, domestic dust mite allergens, sensitization.

Financing. The study was financially supported by the BRFBR (Agreement M20-013 of May 04, 2020).

Acknowledgements. Our thanks to the reviewer.

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Information about authors:
Zavodnik L.B. – Candidate of Medical Sciences, associate professor of the Chair of Theory of Physical Culture & Sports Medicine, Grodno State University named after Yanka Kupala,
ORCID: https://orcid.org/0000-0001-8108-9454;
Khokha R.N. – Candidate of Medical Sciences, associate professor of the Chair of Childhood Diseases No.2, Grodno State Medical University,
ORCID: https://orcid.org/0000-0002-1002-1783;
Khokha A.M. – Doctor of Medical Sciences, professor of the Chair of Pharmacology and Physiology, Grodno State Agrarian University.

Correspondence address: Republic of Belarus, 230003, Grodno, 32 Zacharova str., Grodno State University named after Yanka Kupala, Chair of Theory of Physical Culture & Sports Medicine. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Lev B. Zavodnik.

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