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DOI: https://doi.org/10.22263/2312-4156.2020.6.7

Zavodnik L.B.1, Khokha R.N.2, Khokha A.M.3
Sensibilization to the allergens of domestic dust mites in children. Part 2
1Grodno State University named after Yanka Kupala, Grodno, Republic of Belarus
2Grodno State Medical University, Grodno, Republic of Belarus
3Grodno State Agrarian University, Grodno, Republic of Belarus

Vestnik VGMU. 2020;19(6):7-19.

Abstract.
Recent studies indicate that in patients with atopic phenotype, polymorphisms of some genes can influence the level of sensitivity to house dust mite allergens and increase the risk of sensitization to dust mites. House dust mites are one of the most important environmental factors, exposure to which may result in symptoms of bronchial asthma or allergic rhinitis. The impact of ticks can also cause systemic reactions. Anaphylaxis associated with eating food contaminated with mites has been described, which is called food tick anaphylaxis (Oral Mite Anaphylaxis; OMA; Pancake Syndrome). Recently, the literature has discussed the role of house dust mites in the development of atopic dermatitis and as a new environmental trigger playing a role in the pathogenesis of irritable bowel syndrome. In the control of allergic diseases caused by allergy to house dust mite, an important role is assigned to the implementation of measures aimed at reducing the exposure to ticks, the effectiveness of which has been studied and proved by numerous investigations. Nowadays, there is convincing evidence of a short-term effect of ASIT in patients with allergic rhinitis caused by tick-born sensitization, at the same time, sufficient evidence of long-term efficacy (risk of developing bronchial asthma) of this treatment method has not been obtained. Chapter 2 of the article outlines recent advances in studying the role of house dust mite allergens in allergic disease development, including improved diagnostic and immunotherapeutic modalities used for these diseases treatment.
Key words: house dust mites, genes, clinical manifestations, allergen-specific immunotherapy.

Financing. The study was financially supported by the BRFBR (Agreement M20-013 of May 04, 2020).

Acknowledgements. Our thanks to the reviewer.

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Information about authors:
Zavodnik L.B. – Candidate of Medical Sciences, associate professor of the Chair of Theory of Physical Culture & Sports Medicine, Grodno State University named after Yanka Kupala,
ORCID: https://orcid.org/0000-0001-8108-9454;
Khokha R.N. – Candidate of Medical Sciences, associate professor of the Chair of Childhood Diseases No.2, Grodno State Medical University,
ORCID: https://orcid.org/0000-0002-1002-1783;
Khokha A.M. – Doctor of Medical Sciences, professor of the Chair of Pharmacology and Physiology, Grodno State Agrarian University.

Correspondence address: Republic of Belarus, 230003, Grodno, 32 Zakharova str., Grodno State University named after Yanka Kupala, Chair of Theory of Physical Culture & Sports Medicine. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Lev B. Zavodnik.

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