DOI: https://doi.org/10.22263/2312-4156.2021.6.99
Movsesyan N.A.1, Zhiltsov I.V.1, Kabanova A.A.1, Plotnikov P.V.2, Torosyan T.A.1
The dynamics analysis of maxillofacial infectious and inflammatory diseases causative agents prevalence and the changes in their sensitivity to antibiotics
1Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
2Medical Consultative Center for Urology and Andrology, Minsk, Republic of Belarus
Vestnik VGMU. 2021;20(6):99-109.
Abstract.
To date, the issue of prevention and treatment of infectious and inflammatory diseases of the maxillofacial region is one of the leading unsolved problems among dental diseases. This pathology has a significant prevalence in the Republic of Belarus and in the world as a whole. The atypical clinical course of these diseases is observed with increasing frequency. There is a need for further study of the etiology and pathogenesis of inflammatory diseases of the maxillofacial region. The purpose of this study was to analyze the dynamics of pathogens prevalence of infectious and inflammatory diseases of the maxillofacial region and the changes in their sensitivity to antibiotics for 2001 and 2015-2020. The results of a bacteriological study of 1209 patients with infectious and inflammatory diseases of the maxillofacial region of odontogenic etiology undergoing inpatient treatment at the dental department of the Vitebsk Regional Clinical Hospital were analyzed. It has been found that over the last 19 years, a shift towards an increase in the number of methicillin-resistant isolates was revealed, which may indicate a decline in the effectiveness of beta-lactam antibiotics as starting empirical antibiotic therapy. The sensitivity of S. aureus and S. epidermidis isolates to cephalosporins, fluoroquinolones, lincosamides tends to decrease, the sensitivity of staphylococci to vancomycin and linezolid remains unchanged for the studied period. Streptococci have demonstrated an increase in their sensitivity to penicillins up to 100%, which indicates the rare use of these antibacterial drugs in dental hospitals. When comparing antibiotic resistance of Streptococcus spp. a tendency to the decreased sensitivity of isolates to cephalosporins of the third generation was revealed.
Key words: maxillofacial area, microorganisms, antibiotic resistance, dentistry.
References
1. Omarova SM, Alieva SF, Osmanov AS. Peculiarities of the structure of antimicrobial therapy in the Department of ChLH of a multidisciplinary hospital for facial surgery. Mezhdunar Nauch-issled Zhurn. 2017;(2 Ch 2):30-3. (In Russ.)
2. Afanasev VV, red. Surgical Dentistry: uchebnik. 3-e izd, pererab. Moscow, RF: GEOTAR-Media; 2016. 400 р. (In Russ.)
3. Stepanov EA, Mitrofanova NN, Stepanov DA, Melnikova VV. Peculiarities of purulent-septic infection in patients with maxillofacial pathology. Izv VUZov Povolzh Region Med Nauki. 2019;(2):50-61. (In Russ.)
4. World Health Organization. Antimicrobial resistance: global report on surveillance 2014. Geneva; 2014. 257 p.
5. Omarova SM, Alieva SF, Osmanov AS, Medzhidova ASh. Microbiological characterization of the in-hospital environment in dental surgery departments. Med Al'm. 2016;(3):166. (In Russ.)
6. Vk D, Srikumar S, Shetty S, Nguyen S, Karunasagar I, Fanning Silent S. Antibiotic resistance genes: A threat to antimicrobial therapy. Int J Infect Dis. 2019;79(1):20. doi: http://dx.doi.org/10.1016/j.ijid.2018.11.063
7. Mitrofanova NN, Lebedev MV, Melnikov VL, Kupriushin AS. On the issue of antibiotic resistance of etiological agents of purulent-inflammatory diseases in patients of the maxillofacial surgery department of a multidisciplinary hospital. Izv VUZov Povolzh Region Med Nauki. 2017;(3):49-56. (In Russ.)
8. Fleisher GM. Treatment of odontogenic phlegmon of the maxillofacial region. Academy. 2017;(5):105-9. (In Russ.)
9. Iaretc IuI. Chronic Wound Infections: Current Concepts and Diagnostic Approaches. Zdravookhranenie. 2016;(7):39-50. (In Russ.)
10. Iakovlev SV, Eliseeva EV, Suvorova MP, Dronov IA, Sidorenko SV, Rafalskii VV, i dr. Strategy and tactics for the rational use of antimicrobials in outpatient practice. Eurasian Clinical Guidelines. 2016. Consilium Medicum Pediatriia. 2017;(1):17-25. (In Russ.)
11. Kabanova AA. Antibiotic resistance of the main pathogens of infectious and inflammatory diseases of the maxillofacial region detected in the hospitals of the regional centers of the Republic of Belarus. Zhurn GrGMU. 2017;(2):186-91. (In Russ.)
Information about authors:
Movsesyan N.A. – Master of Medical Sciences, postgraduate of the Chair of Pediatric Dentistry & Orthodontics with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
Zhiltsov I.V. – Doctor of Medical Sciences, associate professor, head of the Chair of Evidence-Based Medicine & Clinical Diagnostics of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
Kabanova A.A. – Doctor of Medical Sciences, associate professor, head of the Chair of Maxillofacial Surgery & Operative Dentistry with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
Plotnikov P.V. – Candidate of Medical Sciences, associate professor, urologist, Minsk Center for Urology and Andrology;
Torosyan T.A. – Candidate of Medical Sciences, associate professor of the Chair of Maxillofacial Surgery & Operative Dentistry with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210009, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Pediatric Dentistry & Orthodontics with the course of the Faculty for Advanced Training & Retraining. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Narine A. Movsesyan.
