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DOI: https://doi.org/10.22263/2312-4156.2019.4.7

Беляева Л.Е., Павлюкевич А.Н.
Раннее программирование заболеваний человека и использование нутрицевтиков с профилактической целью: фокус на рыбий жир. Обзор литературы. Часть 1
Витебский государственный ордена Дружбы народов медицинский университет, г. Витебск, Республика Беларусь

Вестник ВГМУ. – 2019. – Том 18, №4. – С. 7-16.

Резюме.
В первой части обзора проанализированы имеющиеся в научной литературе результаты экспериментальных, клинических и эпидемиологических исследований, посвященных изучению последствий, возникающих при действии стрессоров в пренатальном периоде. Рассмотрены основные механизмы программирования болезней у организмов, чьи матери во время беременности подвергались действию разного рода стрессоров. Предложен подход к минимизации последствий пренатального стресса с помощью нутрицевтика рыбьего жира, содержащего длинноцепочечные омега-3 полиненасыщенные жирные кислоты – эйкозапентаеновую (ЭПК) и докозагексаеновую (ДГК). В первой части обзора обсуждены пути и особенности метаболизма этих полиненасыщенных жирных кислот в организме.  
Ключевые слова: пренатальный стресс, раннее программирование заболеваний человека, эпигенетика, длинноцепочечные омега-3 полиненасыщенные жирные кислоты.

Литература

1. Об утверждении Государственной программы «Здоровье народа и демографическая безопасность Республики Беларусь» на 2016-2020 годы : постановление Совета Министров Респ. Беларусь, 14 марта 2016 г., № 200 // Нац. реестр правовых актов Респ. Беларусь. – 2016. – N 5/41840.
2. Barker, D. J. In utero programming of chronic diseases / D. J. Barker // Clin. Sci. (Lond.). – 1998 Aug. – Vol. 95, N 2. – P. 115–128.
3. Беляева, Л. Е. Гинекологическая эндокринология: патофизиологические основы / Л. Е. Беляева, В. И. Шебеко. – Москва : Мед. лит., 2009. – 256 с.
4. Alexander, B. T. Fetal programming and cardiovascular pathology / B. T. Alexander, J. H. Dasinger, S. Intapad // Compr. Physiol. – 2015 Apr. – Vol. 5, N 2. – P. 997–1025.
5. Fetal programming of neuropsychiatric disorders by maternal pregnancy depression: a systematic mini review / R. Robinson [et al.] // Pediatr. Res. – 2019 Jan. – Vol. 85, N 2. – P. 134–145.
6. The association between subjective maternal stress during pregnancy and offspring clinically diagnosed psychiatric disorders / R. Brannigan [et al.] // Acta. Psychiatr. Scand. – 2019 Apr. – Vol. 139, N 4. – P. 304–310.
7. Prenatal nutrition, epigenetics and schizophrenia risk: Can we test causal effects? / J. B. Kirkbride [et al.] // Epigenomics. – 2012 Jun. – Vol. 4, N 3. – P. 303–315.
8. Abolition of prenatal lipopolysaccharide-induced reproductive disorders in rat male offspring by fulvestrant / M. S. Izvolskaia [et al.] // Andrologia. – 2019 Apr. – Vol. 51, N 3. – P. e13204.
9. Disruptions in the reproductive system of female rats after prenatal lipopolysaccharide-induced immunological stress: role of sex steroids / V. M. Ignatiuk [et al.] // Stress. – 2019 Jan. – Vol. 22, N 1. – P. 133–141.
10. Prenatal Maternal Distress and Allergic Diseases in Offspring: Review of Evidence and Possible Pathways / D. I. Suh [et al.] // Allergy Asthma Immunol. Res. – 2017 May. – Vol. 9, N 3. – P. 200–211.
11. Association between prenatal particulate air pollution exposure and telomere length in cord blood: Effect modification by fetal sex / M. J. Rosa [et al.] // Environ Res. – 2019 May. – Vol. 172. – P. 495–501.
12. Maternal stress and early-onset colorectal cancer / Q. Zhang [et al.] // Med. Hypotheses. – 2018 Dec. – Vol. 121. – P. 152–159.
13. Sharma, A. Transgenerational epigenetics: Integrating soma to germline communication with gametic inheritance / A. Sharma // Mech. Ageing Dev. – 2017 Apr. – Vol. 163. – P. 15–22.
14. Klose, R. J. Genomic DNA methylation: the mark and its mediators / R. J. Klose, A. P. Bird // Trends Biochem. Sci. – 2006 Feb. – Vol. 31, N 2. – P. 89–97.
15. Global epigenomic reconfiguration during mammalian brain development / R. Lister [et al.] // Science. – 2013 Aug. – Vol. 341, N 6146. – P. 1237905.
16. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain / J. U. Guo [et al.] // Cell. – 2011 Apr. – Vol. 145, N 3. – P. 423–434.
17. Maor, G. L. The alternative role of DNA methylation in splicing regulation / G. L. Maor, A. Yearim, G. Ast // Trends Genet. – 2015 May. – Vol. 31, N 5. – P. 274–280.
18. The role of DNA methylation in directing the functional organization of the cancer epigenome / F. D. Lay [et al.] // Genome Res. – 2015 Apr. – Vol. 25, N 4. – P. 467–477.
19. Kouzarides, T. Chromatin modifications and their function / T. Kouzarides // Cell. – 2007 Feb. – Vol. 128, N 4. – P. 693–705.
20. Oliver, S. S. Dynamic Interplay between histone H3 modifications and protein interpreters: emerging evidence for a «histone language» / S. S. Oliver, J. M. Denu // Chembiochem. – 2011 Jan. – Vol. 12, N 2. – P. 299–307.
21. Price, B. D. Chromatin Remodeling at DNA Double Strand Breaks / B. D. Price, A. D. D’Andrea // Cell. – 2013 Mar. – Vol. 152, N 6. – P. 1344–1354.
22. Effects of histone acetylation, ubiquitination and variants on nucleosome stability / W. Li [et al.] // Biochem. J. – 1993 Dec. – Vol. 296, pt. 3. – P. 737–744.
23. Dehennaut, V. O-GlcNAcylation, an Epigenetic Mark. Focus on the Histone Code, TET Family Proteins, and Polycomb Group Proteins / V. Dehennaut, D. Leprince, T. Lefebvre // Front. Endocrinol. (Lausanne). – 2014 Sep. – Vol. 5. – P. 155.
24. Rousseaux, S. Histone Acylation beyond Acetylation: Terra Incognita in Chromatin Biology / S. Rousseaux, S. Khochbin // Cell. J. – 2015 Spring. – Vol. 17, N 1. – P. 1–6.
25. Feng, S. Epigenetic reprogramming in plant and animal development / S. Feng, S. E. Jacobsen, W. Reik // Science. – 2010 Oct. – Vol. 330, N 6004. – P. 622–627.
26. Reik, W. Stability and flexibility of epigenetic gene regulation in mammalian development / W. Reik // Nature. – 2007 May. – Vol. 447, N 7143. – P. 425–432.
27. Maternal exposure to particulate air pollution and term birth weight: a multi-country evaluation of effect and heterogeneity / P. Dadvand [et al.] // Environ. Health. Perspect. – 2013 Mar. – Vol. 121, N 3. – P. 267–373.
28. Coronary heart disease after prenatal exposure to the Dutch famine, 1944-45 / T. J. Roseboom [et al.] // Heart. – 2000 Dec. – Vol. 84, N 6. – P. 595–598.
29. King, B. R. Placental corticotrophin-releasing hormone, local effects and fetomaternal endocrinology / B. R. King, R. C. Nicholson, R. Smith // Stress. – 2001 Dec. – Vol. 4, N 4. – P. 219–233.
30. Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta / B. G. Robinson [et al.] // Proc. Natl. Acad. Sci. USA. – 1988 Jul. – Vol. 85, N 14. – P. 5244–5248.
31. Prenatal maternal cortisol concentrations predict neurodevelopment in middle childhood / E. P. Davis [et al.] // Psychoneuroendocrinology. – 2017 Jan. – Vol. 75. – P. 56–63.
32. Prenatal corticosterone exposure programs sex-specific adrenal adaptations in mouse offspring / J. S. Cuffe [et al.] // J. Endocrinol. – 2017 Jan. – Vol. 232, N 1. – P. 37–48.
33. Reduced placental 11beta-hydroxysteroid dehydrogenase type 2 mRNA levels in human pregnancies complicated by intrauterine growth restriction: an analysis of possible mechanisms / C. L. McTernan [et al.] // J. Clin. Endocrinol. Metab. – 2001 Oct. – Vol. 86, N 10. – P. 4979–4983.
34. Inhibition of placental 11beta-hydroxysteroid dehydrogenase type 2 by catecholamines via alpha-adrenergic signaling / S. Sarkar [et al.] // Am. J. Physiol. Regul. Integr. Comp. Physiol. – 2001 Dec. – Vol. 281, N 6. – P. R1966–R1974.
35. Oxygen regulation of placental 11 beta-hydroxysteroid dehydrogenase 2: physiological and pathological implications / N. Alfaidy [et al.] // J. Clin. Endocrinol. Metab. – 2002 Oct. – Vol. 87, N 10. – P. 4797–4805.
36. Proinflammatory cytokines inhibit human placental 11beta-hydroxysteroid dehydrogenase type 2 activity through Ca2+ and cAMP pathways / I. Kossintseva [et al.] // Am. J. Physiol. Endocrinol. Metab. – 2006 Feb. – Vol. 290, N 2. – P. E282–E288.
37. Maternal prenatal anxiety and downregulation of placental 11beta-HSD2 / K. J. O’Donnell [et al.] // Psychoneuroendocrinology. – 2012 Jun. – Vol. 37, N 6. – P. 818–826.
38. Xiong, F. Role of the hypothalamic-pituitary-adrenal axis in developmental programming of health and disease / F. Xiong, L. Zhang // Front. Neuroendocrinol. – 2013 Jan. – Vol. 34, N 1. – P. 27–46.
39. Chrousos, G. P. Interactions between the hypothalamic-pituitary-adrenal axis and the female reproductive system: clinical implications / G. P. Chrousos, D. J. Torpy, P. W. Gold // Ann. Intern. Med. – 1998 Aug. – Vol. 129, N 3. – P. 229–240.
40. Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree / C. Krebs [et al.] // Am. J. Obstet. Gynecol. – 1996 Dec. – Vol. 175, N 6. – P. 1534–1542.
41. Myatt, L. Placental adaptive responses and fetal programming / L. Myatt // J. Physiol. – 2006 Apr. – Vol. 572, pt. 1. – P. 25–30.
42. Regulation of human placental development by oxygen tension / O. Genbacev [et al.] // Science. – 1997 Sep. – Vol. 277, N 5332. – P. 1669–1672.
43. Brower, V. Nutraceuticals: poised for healthy slice of the healthcare market? / V. Brower // Nat. Biotechnol. – 1998 Aug. – Vol. 16, N 8. – P. 728–731.
44. USDA National Nutrient Database for Standard Reference [Electronic resource] / United States Department of Agriculture, Agricultural Research Service. – 2019. – Mode of access: https://ndb.nal.usda.gov/ndb/foods/show/04589. – Date of access: 13.08.2019.
45. Burdge, G. C. Dietary alpha-linolenic acid and health-related outcomes: a metabolic perspective / G. C. Burdge, P. C. Calder // Nutr. Res. Rev. – 2006 Jun. – Vol. 19, N 1. – P. 26–52.
46. Abedi, E. Long-chain polyunsaturated fatty acid sources and evaluation of their nutritional and functional properties / E. Abedi, M. A. Sahari // Food Sci. Nutr. – 2014 Sep. – Vol. 2, N 5. – P. 443–463.
47. Pathways of polyunsaturated fatty acid utilization: Implications for brain function in neuropsychiatric health and disease / J. J. Liu [et al.] // Brain. Res. – 2015 Feb. – Vol. 1597. – P. 220–246.
48. Dietary intake of trans fatty acids and systemic inflammation in women / D. Mozaffarian [et al.] // Am. J. Clin. Nutr. – 2004 Apr. – Vol. 79, N 4. – P. 606–612.
49. Effects of cigarette smoke on cell viability, linoleic acid metabolism and cholesterol synthesis, in THP-1 cells / S. Ghezzi [et al.] // Lipids. – 2007 Jul. – Vol. 42, N 7. – P. 629–636.
50. Cicero, A. F. G. Krill oil: evidence of a new source of polyunsaturated fatty acids with high bioavailability/ A. F. G. Cicero, A. Colletti // Clin. Lipidol. – 2015. – Vol. 10. – P.1–4.

Сведения об авторах:
Беляева Л.Е. – к.м.н., доцент, заведующая кафедрой патологической физиологии, Витебский государственный ордена Дружбы народов медицинский университет;
Павлюкевич А.Н. – м.м.н., ассистент кафедры патологической физиологии, Витебский государственный ордена Дружбы народов медицинский университет.

Адрес для корреспонденции: Республика Беларусь, 210009, г. Витебск, пр. Фрунзе, 27, Витебский государственный ордена Дружбы народов медицинский университет, кафедра патологической физиологии. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Беляева Людмила Евгеньевна.

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