Шейбак В.М.
Транспортная функция сывороточного альбумина: цинк и жирные кислоты
УО «Гродненский государственный медицинский университет», Республика Беларусь
Резюме.
В обзоре представлены особенности структуры и свойств альбумина, их связь с антиоксидантной и транспортной функциями. Тиоловые группы альбумина вносят наибольший вклад в формирование общего пула тиолов плазмы и влияют на редокс-состояние осуществляя тиол-дисульфидный обмен и образовывая смешанные дисульфиды с низкомолекулярными серосодержащими соединениями. Представлены данные о транспорте цинка и жирных кислот альбумином. Связывание альбумина со свободными жирными кислотами изменяет легко обмениваемый пул Zn2+ в плазме. Жирные кислоты способны модулировать сродство альбумина в отношении Zn2+ при физиологических уровнях жирных кислот, что влияет на обеспеченность тканей цинком и может вносить вклад в регуляцию состояний, сопровождающихся повышенным уровнем свободных жирных кислот. Показана конкуренция между альбумином и гликопротеинами плазмы за связывание свободных катионов цинка.
Ключевые слова: альбумин, жирные кислоты, цинк, гликопротеин.
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Сведения об авторах:
Шейбак В.М. – д.м.н., профессор кафедры биологической химии УО «Гродненский государственный медицинский университет».
Адрес для корреспонденции: Республика Беларусь, 230009, г. Гродно, ул. Горького, 80, УО « Гродненский государственный медицинский университет», кафедра биологической химии. Е-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Шейбак Владимир Михайлович.
