Karpuk I.Y., Novikov D.K., Karpuk N.A., Semenova I.V.
The role of granulocytes in the pathogenesis of the development of an allergy to dentoprosthetic materials and its diagnosis method
Abstract. The purpose of the present research was to establish the role of granulocytes in the pathogenesis of the development of an allergy to dentoprosthetic materials; to work out and clinically test the method of revealing sensitization to metals by means of an estimation of the specific granulocytes damage induced by them.
Patients with an allergy to metals (n=61) and those without it (n=26) were examined.
As a result of this study it was determined that the diagnostic efficiency of allergen induced damage of leukocytes reaction with the solution of salt NiCl2 made up 86,9%, with the solution of salt CrCl3 – 85,9%, with the solution of salt CoCl2 – 92%, with the solution of salt CuCl2 – 85,2% that testifies to the possibility to use allergen induced damage of leukocytes reaction for the diagnosing of an allergy to metals.
We conclude that the suggested approach to the diagnosis of an allergy to metals takes into account important stages of allergic reaction development and is safe for patients.
Key words: allergy, granulocytes, dentoprosthetic materials, pathogenesis, diagnosis.
