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Nemtsov L.M.
Pseudomembranous colitis as a multidiscipline problem

Abstract.
Toxin - producing strains of Clostridium difficile are responsible for up to 20% of all of antibiotic-associated diarrheas (AАD) and 40-45% of cases of nosocomial AAD in the countries of Europe and North America with a high risk of the development of pseudomembranous colitis (PMC) and life-threatening complications, especially in  case of delayed diagnosing and inadequate therapy. AАD caused by Clostridium difficile is a multi-discipline problem concerning many branches of medicine, including not only epidemiology, clinical microbiology and infectious diseases, but also gastroenterology, abdominal surgery, oncology, intensive care, and some others. This article provides a survey of researches on the diagnosis, treatment and prevention of PMC. Recently PMC has become a common and aggressive hospital infection associated with antibiotic therapy, which may occur in patients with various medical and surgical pathology. The appearance of diarrhea, hyperthermia, hyperleukocytosis and the signs of endogenous intoxication after administered antibiotic therapy should be considered as a ground for targeted diagnosing of Clostridium difficile-associated colitis (PMC) with the use of laboratory tests. Duly diagnosis and appropriate treatment can prevent the development of severe forms of PMC, which are accompanied by complications and sometimes require surgical treatment. To prevent PMС rationalization of schemes and modes of antibiotic therapy is necessary. Adequate awareness of different medical specialists as regards PMC should be an important component of clinical antibiotic therapy for prevention and early detection of it. Treatment of severe and recurrent PMC forms remains a very challenging task because of a limited number of effective medications.
Key words: pseudomembranous colitis, Clostridium difficile, antibiotic-associated diarrhea.

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