Semyonova I.V., Vykhristenko L.R.
Complex evaluation of the clinical efficacy of allergen specific immunotherapy in pollen allergy
The purpose of this study was to evaluate the clinical efficacy of preseasonal allergen specific immunotherapy (ASIT) in pollinosis by using a complex of standardized parameters.
The study involved 56 patients with pollinosis (28 men and 27 women), in whom for the first time preseasonal subcutaneous ASIT was conducted. The symptoms of the disease were evaluated in a season prior to treatment and after treatment. Clinical manifestations of rhinoconjunctivitis were evaluated according to T5SS scale, those of asthma - by questionnaire AST-test, the quality of life (QOL) - by questionnaire RQLQ. In addition, the need to use drugs (whether the patients used them or did not use) was taken into account.
As a result of the study it was found that on the background of ASIT rhinoconjunctival (p<0,001) and bronchospastic (p<0,001) manifestations of pollen allergy significantly reduced. In the examined patients the intake of antihistamines (p<0,05), intranasal corticosteroids (p<0,05), decongestants (p<0,001), cromones (p<0,001) decreased as well. After the course of treatment the reduction in the total RQLQ score (p<0,001) was observed, that testified to the improvement of patients’ life quality after therapy. The analysis of correlation between the decrease in rhinoconjunctivitis symptoms severity and improvement of QOL parameters showed the interrelationship between these two signs (p<0,05).
The use of complex parameters to assess the effectiveness of the given therapy has shown that preseasonal subcutaneous ASIT is a more effective treatment for pollen allergy than pharmacotherapy, it objectively reflects the success of treatment, reduces rhinoconjunctival and bronchospastic symptoms, leads to the decrease in the need of drugs, improves patients’ life quality.
Key words: pollinosis, sensitization, allergen specific immunotherapy.