Kosinets A.N., Frolova A.V., Bulavkin V.P., Okulich V.K.
Antibiotic resistance. New possibilities to antibacterially combat it
Abstract.
According to «Toronto declaration to combat antimicrobial resistance» (Toronto, 2000) and «WHO Global Strategy to restrain antimicrobial resistance» (Geneva, 2001) one of the ways to cope with drug resistance is the elaboration and introduction into the practice of new antimicrobial agents. Therefore the search for promising bioactive compounds effective against multidrug-resistant pathogens and possessing no toxic action seems to be urgent. The original herbal medicine «PhytoMP» made of Macleaya microcarpa and Plantago major has been tested by us in the treatment of patients with wound infection. It has been established that its convenient dosage form and prolonged effect, multifunctionality on variation of its components enable the provision of adequate antimicrobial therapy in accordance with the phase of the wound healing. Using this powder at components ratio «Macleaya microcarpa / Plantago major» o 2:1 reduces the contamination of wounds with staphylococcus and cleanses the wound surface on the third day, contributes to reduction of the first phase of wound healing process and patients’ hospital stay by 2,21 bed-days in contradiction to those who receive traditional antibacterial remedies. It has also been shown that new antimicrobial materials with impregnated or sprayed micro- and nanoparticles of copper and silver allow as distinct from the traditional cotton-gauze bandages to clean the experimental wound surface out of microorganisms, excluding its trauma.
Key words: wound microflora, antibiotic resistance, «PhytoMP», dressing material.
References
1. Abaev YuK. Spravochnik khirurga. Rany i ranevaia infektsiia [Reference book of the surgeon. Wounds and wound fever]. Rostov n/D., RF: Feniks; 2006. 427 р.
2. Beloborodov VB. Problemy antibakterial'noi terapii khirurgicheskikh infektsii, vyzvannykh rezistentnoi grampolozhitel'noi floroi [Problem of antibiotic therapy of surgical infections caused by resistant gram-positive]. Suchasnі іnfektsії. 2010;(4):108-15.
3. Romanova YuM, Didenko LV, Tolordava ER, Gintsburg AL. Bioplenki patogennykh bakterii i ikh rol' v khronizatsii infektsionnogo protsessa. Poisk sredstv bor'by s bioplenkami [Biomembranulas of pathogenic bacteria and their role in synchronization of infectious process]. Vestnik RAMN. 2011;(10):31-9.
4. Briskin BS. Vnutribol'nichnaia infektsiia i posleoperatsionnye oslozhneniia s pozitsii khirurga [An intrahospital infection and postoperative complications from the surgeon's positions]. Infektsionnaia i antimikrobnaia terapiia. 2001;2(45):124-8.
5. Aslam S, Darouiche RO. Role of antibiofilm-antimicrobial agents in controlling device-related infections. Int J Artif Organs. 2011 Sep;34(9):752-8.
6. Nichols RL. Surgical infections: prevention and treatment (1965-1995). Am J Surg. 1996 Jul;172(1):68-74.
7. The WHO policy package to combat antimicrobial resistance. Bulletin of the World Health Organization. 2011;(89):390-2.
8. Kozlov RS. Klinicheskoe znachenie rezistentnosti grampolozhitel'nykh bakterii [Clinical value of resistance of Gram-positive bacteria]. Infektsii v khirurgii. 2009;7(app. 1):3-10.
9. Strachunskii LS, red Peshere ZhK, red Dedlindzher PE, red. Politika primeneniia antibiotikov v khirurgii [Policy of application of antibiotics in surgery]. Klinicheskaia mikrobiologiia i antimikrobnaia khimioterapiia. 2003;5(4):302-17.
10. Aкimitsu N, Hamamoto H, Inoue R, Shoji M, Akamine A, Takemori K, Hamasaki N, Sekimizu K. Increase in resistance of methicillinresistant S. aureus to β-lactams caused by mutations conferring resistance to benzalkonium chloride, a disinfectant widely used in hospitals. Antimicrob Agents Chemother. 1999 Dec;43(12):3042-3.
11. Kapil A. The challenge of antibiotic resistance: need to contemplate. Indian J Med Res. 2005 Feb;121(2):83-91.
12. Belotserkovskii BZ, Gel'fand EB, Protsenko DN, Popov TV, Krasnov VG. Antibiotiki v khirurgii i intensivnoi terapii [Antibiotics in surgery and an intensive care]. Infektsii v khirurgii. 2009;7(2):70-6.
13. Barkhatova NA. Dinamika rezistentnosti vozbuditelei lokal'nykh i generalizovannykh form infektsii miagkikh tkanei [Dynamics of resistance of originators of local and generalized forms of infections of soft tissues]. Kazanskii meditsinskii zhurnal. 2009;90(3):385-90.
14. Blatun LA. Sovremennye osnovy obshchei antibakterial'noi terapii ranevoi infektsii [Modern bases of the general antibacterial therapy of a wound fever]. V: Blatun LA, Fedorov VD, red. Svetukhin AM, red. Izbrannyi kurs lektsii po gnoinoi khirurgii. Moscow, RF: Miklosh; 2005. p. 328-352.
