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Shevlyakov V.V., Filonyuk V.A., Rybina T.M., Chernyshova Е.V., Kardash O.F., Ehrm G.I., Buynitskaya A.V., Studenichnik Т.S.
Health status of the employees engaged in biotechnological productions

Abstract.
It has been found out that the employees of 4 biotechnological productions located in Minsk, Skidel, Bobruisk, who had occupationally been exposed to contact with industrial microorganisms show a rather high rate of prevalence of subjective and objective symptoms of major organs and systems disorders which is 2,8-16 times higher than that of the comparison group (р<0,05-0,001). The disorders mainly had a typical and characteristic allergic focus, multisystem and combination traits, regularly increased with the length of work experience of the employees which characterizes them as production-caused. Restrictive changes in the bronchi have been revealed in the employees whose work experience was more than 15 years, moderate reduction of the subjective assessment of functional health status in terms of «health» has been found in the employees with work experience of 5-10 years.
The number of disability days due to diseases per 100 employees, and the average duration of cases in the group of employees exposed to microbiological factors are significantly higher than those in the comparison group. It is more common for the employees occupied under the impact of industrial microbiological factor to suffer from acute respiratory infections of the upper respiratory tract at the age of 25 with 2,5 year work experience (the employees with little work experience occupied under the impact of industrial microorganisms most frequently fall ill with influenza which defines the priority indications for influenza vaccine prevention measures among this category of employees), whereas in the comparison group these diseases are diagnosed more often at a later age - 38,8 (10,5) years (p<0,05).
To ensure the safe circulation of microorganisms-producers and biological products on their basis it is both important and necessary to improve and develop modern system of early diagnosis and prevention of professional and work-related diseases in employees engaged in biotechnological productions.  
Key words: biotechnological production, biologically harmful factors, employees health status.

References

1. Bondarenko NV, Voronin KE, Grinberg ShM. Sostoianie i perspektivy razvitiia biologicheskogo metoda zashchity rastenii v SSSR [State and prospects of development of a biological method of protection of plants in the USSR]. Sel'sko-khoziaistvennaia biologiia. 1979;14(6):675–82.
2. Murza VI. K voprosu o patogennosti i sanitarno-gigienicheskikh usloviiakh proizvod-stva entobakterina [On the pathogenicity and sanitary conditions of production entobacterin]. V: Gigiena primeneniia, toksikologiia pestitsidov i klinika otravlenii. Moskva, RF: Meditsina; 1973. Vyp. 10. р. 161-165.
3. Garas'ko EV. Problemy biobezopasnosti rabotaiushchikh [Problems of biological safety of workers]. V: Sovremennoe sostoianie rossiiskoi biotekhnologii: materialy nauch.-prakt. konf. Moscow, RF; 2003. р. 16.
4. Karpova NI, Setko NP. Mediko-biologicheskie i gigienicheskie problemy proizvodstva belkovo-vitaminnykh kontsentratov [Medicobiological and hygienic problems of production of albuminous and vitamin concentrates]. Leningrad, RF; 1980. p. 57–59.
5. Artamonova VG, Svitina HH. Sovremennye aspekty profilaktiki bronkholegochnoi patologii u rabotaiushchikh v biotekhnologicheskom proizvodstve [Modern aspects of the prevention of respiratory disease in working in the biotechnological production of]. Gigiena truda i prof. zabolevaniia. 1991;(3):33-4.
6. Kormil'tseva IV, Koval' EZ, Savchenko IL, Blotskaia LL. Dermatomikozy u rabochikh predpriiatii mikrobiologicheskoi promyshlennosti [Ringworm of the workers of enterprises microbiological industry]. Gigiena truda i prof. zabolevaniia. 1992;(2):14-6.
7. Shleikin AG. Patogeneticheskie aspekty diagnostiki i profilaktiki patologicheskikh sostoianii, vyzyvaemykh produktami mikrobiologicheskogo sinteza [Pathogenetic aspects of diagnosis and prevention of pathological conditions caused by the products of microbiological synthesis]. Gigiena i sanitariia. 1990;(8):45-8.
8. Petrov RV, Oradovskaia IV. Klinicheskaia dolaboratornaia diagnostika immunologicheskoi nedostatochnosti v sisteme massovykh immunologicheskikh obsledovanii naseleniia [Clinical dolaboratorny diagnostics of an immunologic failure in system of mass immunologic inspections of the population]. V: Materialy Vsesoiuznoi konferentsii «Metodologiia, organizatsiia i itogi massovykh immunologicheskikh obsledovanii». Angarsk, RF; 1987. р. 215-234.
9. Varenin VA, Sorokin GA, Plekhanov VP. Anamnesticheskii metod izucheniia prichinno-sledstvennykh sviazei mezhdu sostoianiem obshchestvennogo zdorov'ia, proizvodstvennymi, ekologicheskimi i sotsial'nymi faktorami [Anamnestic method of studying of relationships of cause and effect between a condition of public health, production, ecological and social factors]. Meditsina truda i promyshlennaia ekologiia. 1995;(11):40–2.
10. Burmak IuG. Mekhanizmy razvitiia zabolevanii vnutrennikh organov u rabochikh koksokhimicheskogo proizvodstva i vozmozhnye puti ikh profilaktiki [Mechanisms for the development of internal diseases in workers of coke production and possible prevention]: avtoref. dis. … d-ra med. nauk: 14.00.05. Saint-Petersburg, RF; 1996. 34 р.
11. Koval'skii Ia, red. Kozerovskii A, red. Radvan L, red. Otsenka funktsii legkikh pri zabolevaniiakh dykhatel'noi sistemy [Evaluation of pulmonary function in diseases of the respiratory system]. Warsaw, Poland: Institut tuberkuleza i boleznei legkikh v Varshave; 2008. 428 р.
12. Khaitov RM, Pinegin BV. Vtorichnye immunodefitsity: klinika, diagnostika, lechenie [Secondary immunodeficiency: clinical features, diagnosis, treatment]. Immunologiia. 1999;(1):14-7.
13. Shevliakov VV. Printsipy i podkhody profilaktiki profallergozov putem tselenapravlennogo profotbora na allergoopasnye raboty [The principles and approaches of prophylaxis of professional allergoses by purposeful professional selection for allergic dangerous works]. V: Ekologicheskoe modelirovanie i optimizatsiia v usloviiakh tekhnogeneza: tez. dokl. 1 Mezhdunar. konf. Soligorsk, RB; 1996. p. 78–79.
14. Sasson, A. Biotekhnologiia: sversheniia i nadezhdy [Biotechnology: achievements and hopes]. Moscow, RF: Mir; 1987. 412 р.
15. Ivko NA. et al. Pokazateli immunologicheskoi rezistentnosti kozhi i slizistykh obolochek nosoglotki v otsenke sostoianiia zdorov'ia i kachestva proizvodstvennoi sredy pri massovykh obsledovaniiakh rabochikh [Indicators of immunologic resistance of a skin and mucosas of a nasopharynx in an assessment of a state of health and quality of production medium at mass inspections of workers]. V: Sovremennye problemy infektsionnoi patologii cheloveka (epidemiologiia, klinika, mikrobiologiia, virusologiia, immunologiia): tez. dokl. I itogovoi nauch.-prakt. konf. – Minsk, RB; 1998. p. 210–211.
16 Pankova VB. Aktual'nye problemy profpatologii na sovremennom etape [Actual problems of occupational pathology at the present stage]. Gigiena truda i prof. zabolevaniia. 1990;(7):1-5.
17. Novikov DK. Klinicheskaia allergologiia [Clinical falergy]: sprav. posobie. Minsk, RB: Vysheishaia shkola; 1991. 511 р.
18. Brusilovskii ES. Diagnostika allergicheskikh zabolevanii sistemy pishchevareniia khimicheskoi etiologii [Diagnosis of allergic diseases of the digestive system of chemical etiology]. V: Professional'nye allergozy: seminar. Riga, Latvia; 1976. р. 38-42.
19. Abramov VV. Integratsiia immunnoi i nervnoi system [Integration of the immune and nervous systems]. Immunologiia. 1999;(3):62-4.
20. Gerasimova MM. Obosnovanie neobkhodimosti vneseniia v spisok professional'nykh zabolevanii allergicheskikh vaskulitov, obuslovlennykh vozdeistviem antibiotikov [Justification of the need to make a list of occupational diseases of allergic vasculitis caused by exposure to antibiotics]. Gigiena truda i prof. zabolevaniia. 1990;(8):19-24.
21. Ado AD. Obshchaia allergologiia [General allergy]: (rukovodstvo dlia vrachei). 2-e izd., pererab. i dop. Moscow, RF: Meditsina; 1978. 463 р.
22. Khomenko AG, red. Miuller ST, red. Shilling GV, red. Ekzogennyi allergicheskii al'veolit [Extrinsic allergic alveolitis]. Moscow, RF: Meditsina; 1987. 272 р.
23. Iarygin NE, Nasonova VA, Potekhina RN. Sistemnye allergicheskie vaskulity [Systemic allergic vasculitis]. Moscow, RF: Meditsina; 1980. 328 р.
24. Izrailet LI. Professional'naia patologiia pri vozdeistvii antibiotikov v proizvodstvennykh usloviiakh (Oleandomitsin, nistatin, grizeoful'vin, tetratsiklin, biovit) [Professional pathology when exposed to antibiotics in the production environment (oleandomycin, nystatin, griseofulvin, tetracycline, Biovit)]: avtoref. dis. ... d-ra med. nauk: 756. Moscow, RF; 1970. 38 р.
25. Pytskii VI, Adrianova NV, Artomasova AV. Allergicheskie zabolevaniia [Allergic diseases]. Moscow, RF; 1984. 272 р.

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