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Asiryan E.G., Golubeva A.I., Matsuk O.N., Matyushchenko O.V.
The peculiarities of clinical and laboratory investigations in asthmatic children

Abstract.
Objectives. To determine the peculiarities of the anamnesis, clinical picture, the results of laboratory investigations and allergic examination of children with bronchial asthma.
Material and methods. We have examined 144 children with bronchial asthma; clinical, laboratory and instrumental methods of diagnosis, skin scratch tests with household allergens have been used and serum level of total IgE has been determined.
Results. In the examined group of children 84 (58,3%) patients had mild asthma and 60 (41,7%) children had its moderate form. The disease was observed for at least 2 years in 56 (38,9%) children, during more than 2 years - in 88 (61,1%) patients. 76 (52,8%) children had a hereditary predisposition to allergy. Violations according to the obstructive type during spirometry were found in 20 (13,9%) children with moderate bronchial asthma. The associated pathology was found in 92 (63,9%) patients. Asthma was reliably more frequently associated  with some other allergic disease (p<0,05). Eosinophilia in general blood analysis was detected in 87 (60,4%) children. The increase of total IgE level (more than 100 KU/l) in blood serum was observed in 116 (80,6%) children. Positive skin scratch tests with house dust allergen were observed in 42 (29,2%) children. Sensitization to Dermatophagoides pteronyssinus was detected in 46 (31,9%) patients; positive results to Dermatophagoides farinae were obtained in 38 (26,4%) children.
Conclusion. As a result of clinical and laboratory studies in asthmatic children various features of the disease are identified. They should be considered while making a diagnosis of bronchial asthma as well as for the further choice of adequate therapy.
Key words: bronchial asthma, children, total IgE, skin tests.

References

1. Eagan TM, Brøgger JC, Eide GE, Bakke PS. The incidence of adult asthma: a review. Int J Tuberc Lung Dis. 2005 Jun;9(6):603-12.
2. Pocket Guide for Asthma Management and Prevention (for Adults and Children than 5 Years): revised 2014. Available from: www. ginasthma. org.  
3. Papadopoulos NG, Arakawa H, Carlsen KH, Custovic A, Gern J, Lemanske R, Le Souef P, Mäkelä M, Roberts G, Wong G, Zar H, Akdis CA, Bacharier LB, Baraldi E, van Bever HP, de Blic J, Boner A, Burks W, Casale TB, Castro-Rodriguez JA, Chen YZ, El-Gamal YM, Everard ML, Frischer T, Geller M, Gereda J, Goh DY, Guilbert TW, Hedlin G, Heymann PW, Hong SJ, Hossny EM, Huang JL, Jackson DJ, de Jongste JC, Kalayci O, Aït-Khaled N, Kling S, Kuna P, Lau S, Ledford DK, Lee SI, Liu AH, Lockey RF, Lødrup-Carlsen K, Lötvall J, Morikawa A, Nieto A, Paramesh H, Pawankar R, Pohunek P, Pongracic J, Price D, Robertson C, Rosario N, Rossenwasser LJ, Sly PD, Stein R, Stick S, Szefler S, Taussig LM, Valovirta E, Vichyanond P, Wallace D, Weinberg E, Wennergren G, Wildhaber J, Zeiger RS. International consensus on (ICON) pediatric asthma. Allergy. 2012 Aug;67(8):976-97.
4. Fedoseev GB, Trofimov VI. Bronkhial'naia astma [Bronchial asthma]. Saint-Petersburg, RF: Nordmedizdat; 2006. 308 р.
5. Khaitov RM, red. Ilina NI, red. Allergologiia i immunologiia [Allergology and immunology]: nats. ruk. Moscow, RF: GEOTAR-media; 2009. 656 р.
6. Cantani A. Pediatric Allergy, Asthma and Immunology. Springer. 2008. р. 706-708.
7. Zhernosek VF, Diubkova TP. Diagnostika i lechenie allergicheskikh boleznei u detei [Diagnostics and treatment of allergic illnesses at children]: sprav. Minsk, RB: RIVSh; 2013. 120 р.
8. Novikov DK, Novikova VI, Dotsenko EA. Bronkhial'naia astma u vzroslykh i detei [Bronchial asthma at adults and children]. Moscow, RF; Vitebsk, RB; 1998. 187 р.
9. García-Robaina JC, Sánchez I, de la Torre F, Fernández-Caldas E, Casanovas M. Successful management of mite-allergic asthma with modified extracts of Dermatophagoides pteronyssinus and Dermatophagoides farinae in a double-blind, placebo-controlled study. J Allergy Clin Immunol. 2006 Nov;118(5):1026-32.
10. Sun J, Zhang H, Ying W, Qian X. Study on Dermatophagoides pteronyssinus allergens fingerprinting by two-dimensional immunoblotting. J Allergy Clin Immunol. 2005 Feb;115(2):53.
11. Ilina EV, Kurbacheva OM, Ilina NI. Sposoby otsenki kontrolia bronkhial'noi astmy [Ways of an assessment of control of bronchial asthma]. Rossiiskii allergologicheskii zhurnal. 2009;(2):6-17.
12. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, Zuberbier T, Baena-Cagnani CE, Canonica GW, van Weel C, Agache I, Aït-Khaled N, Bachert C, Blaiss MS, Bonini S, Boulet LP, Bousquet PJ, Camargos P, Carlsen KH, Chen Y, Custovic A, Dahl R, Demoly P, Douagui H, Durham SR, van Wijk RG, Kalayci O, Kaliner MA, Kim YY, Kowalski ML, Kuna P, Le LT, Lemiere C, Li J, Lockey RF, Mavale-Manuel S, Meltzer EO, Mohammad Y, Mullol J, Naclerio R, O'Hehir RE, Ohta K, Ouedraogo S, Palkonen S, Papadopoulos N, Passalacqua G, Pawankar R, Popov TA, Rabe KF, Rosado-Pinto J, Scadding GK, Simons FE, Toskala E, Valovirta E, van Cauwenberge P, Wang DY, Wickman M, Yawn BP, Yorgancioglu A, Yusuf OM, Zar H, Annesi-Maesano I, Bateman ED, Ben Kheder A, Boakye DA, Bouchard J, Burney P, Busse WW, Chan-Yeung M, Chavannes NH, Chuchalin A, Dolen WK, Emuzyte R, Grouse L, Humbert M, Jackson C, Johnston SL, Keith PK, Kemp JP, Klossek JM, Larenas-Linnemann D, Lipworth B, Malo JL, Marshall GD, Naspitz C, Nekam K, Niggemann B, Nizankowska-Mogilnicka E, Okamoto Y, Orru MP, Potter P, Price D, Stoloff SW, Vandenplas O, Viegi G, Williams D. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy. 2008 Apr;63(86):8-160.
13. Pampura AN. Diagnostika pishchevoi allergii u detei: problemy i puti resheniia [Diagnostics of food allergy at children: problems and solutions]. Rossiiskii vestnik perinatologii i pediatrii. 2009;54(4):69-77.
14. Baranov AA, red. Khaitov RM, red. Allergologiia i immunologiia [Allergology and immunology]. Moscow, RF: Soiuz pediatrov Rossii; 2010. 248 р.

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