Sheybak V.M.
Transport function of serum albumin: zinc and fatty acids
Education Establishment "Grodno State Medical University", Republic of Belarus
Abstract.
This review deals with the features of the structure and properties of albumin, their relationship with the antioxidant and transport functions. Thiol groups of albumin mostly contribute to the formation of the common pool of plasma thiols and affect the redox state carrying out the thiol-disulfide exchange and forming mixed disulfides with low molecular weight sulfur-containing compounds. The data on the transport of fatty acids and zinc by albumin are presented. Albumin binding with free fatty acids changes readily exchangeable pool of Zn2+ in plasma. Fatty acids are able to modulate the affinity of albumin with respect to Zn2+ on physiological levels of fatty acids which affects the provision of tissues with zinc and may contribute to the regulation of conditions accompanied by the increased levels of free fatty acids. The competition between albumin and plasma glycoproteins for the binding of free zinc cations has been shown.
Key words: albumin, fatty acids, zinc, glycoprotein.
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