Pravada N.S., Budritsky A.M.
Complex therapy with the use of immune preparations in tuberculosis and interferon-gamma system
Education Establishment "Vitebsk State Order of Peoples’ Friendship Medical University", Republic of Belarus
Abstract.
This review paper is devoted to studying the role of interferon-gamma system in patients with pulmonary tuberculosis, as well as modern approaches to correcting these disturbances. Among numerous factors of the pathogenesis of tuberculosis are important reaction mechanisms of delayed hypersensitivity with the production of interferon-gamma (IFN-.) by Th-1 cells, which mobilizes mechanisms and accelerates the maturation of monocytes into macrophages and activates their phagocytic and bactericidal capacity. In a patient suffering from active tuberculosis, depending on the production of these and those cytokines Th-1 or Th-2 immune response is formed. The favourable course of the disease is possible in case of Th-1 immune response. The authors have analyzed the data obtained by native and foreign experts over the last 10 years. The acquired knowledge will enable the improvement of the clinical efficacy of the treatment of patients with pulmonary tuberculosis, the reduction of hospital stay term, the decrease of side effects during treatment, treatment cost cutting.
Key words: interferon-gamma, immunotherapy, tuberculosis.
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