Karpuk I.Y.
The application of vaseline-lanolin basis for diagnosing allergy to nickel
Education Establishment "Vitebsk State Order of Peoples’ Friendship Medical University", Republic of Belarus
Abstract.
Panels for the detection of an allergy to nickel include solutions of their salts in about g/100 ml or mol/l concentrations. However, they can differ in the solvents used in their production (water, alcohol, oils, vaseline), anions (chlorides, sulfates, nitrates, etc.). It causes a certain variability of the received results. Thus, there is a necessity for the determination of the diagnostically most significant basis for metal salts dissolving and for doing skin tests.
The research objective was to develop a technique of diagnosing an allergy to metals by means of application tests with the use of vaseline - lanolin basis for the dissolution of NiCl2 • 6H2O as an allergen by doing application tests for the detection of sensitization to it.
The method of application testing with NiCl2 • 6H2O salt solution on vaseline - lanolin basis to determine sensitization of an organism to nickel has been developed and clinically tried.
Patients with intolerance to metals (n=30) have been examined. The control group was made up of almost healthy subjects (n=30).
This method allows to increase diagnostic sensitivity of the test by 16,7% (рWilcoxon<0,001), without lowering specificity in comparison with the results of doing application tests with vaseline basis, and is characterized by the absence of any doubtful reactions occurring while doing application tests on vaseline basis.
Key words: allergy, nickel salt, skin tests, diagnosis.
References
1. Schnuch A, Uter W, Geier J, Gefeller O. Epidemiology of contact allergy: an estimation of morbidity employing the clinical epidemiology and drug-utilization research (CE-DUR) approach. Contact Dermatitis. 2002 Jul;47(1):32-9.
2. Moiseichik PN, Skepian AN. Formirovanie allergicheskikh reaktsii v zavisimosti ot sochetannogo vozdeistviia gaptenov [Formation of allergic reactions depending on the combined influence of gapten]. V: Sostoianie stomatologicheskoi pomoshchi naseleniiu i puti ee usovershenstvovaniia v usloviiakh perekhodnoi ekonomiki: materialy 3 s"ezda stomatologov Belarusi. Minsk, RB; 1997. р. 213–214.
3. Moiseichik PN, sost, Skepian NA, sost, Velichko LS, sost, Naumovich SA, sost. Prognozirovanie, diagnostika i profilaktika allergicheskikh reaktsii v ortopedicheskoi stomatologii [Forecasting, diagnostics and prophylaxis of allergic reactions in an orthopedic odontology]: metod. pekomendatsii. Minsk, RB; 1999. 23 р.
4. Fedorovich SV, Sokolov SM, Moiseichik PN, Skepian N A. Allergiia v stomatologicheskoi praktike [An allergy in stomatologic practice]. Baranovichi, RB; 2001. 182 р.
5. Lebedev KA, Mitronin AV, Poniakina ID. Neperenosimost' zuboproteznykh materialov [Intolerance of dentoprosthetic materials]. Moscow, RF: Librokom; 2010. 208 р.
6. Gozhaya LD. Allergicheskie i toksiko-khimicheskie stomatity, obuslovlennye materialami zubnykh protezov [The allergic and toksiko-chemical stomatites caused by materials of dentures]: metod. posobie dlia vrachei-stomatologov. Moskva, RF; 2000. 31 р.
7. Poluev VI, Leontiev VK, Shestakov VT. Professional'nye riski i professional'naia otvetstvennost' rabotnikov stomatologicheskogo profilia [Professional risks and professional responsibility of workers of a stomatologic profile]. Stomatologiia dlia vsekh. 2001;(2):40–3.
8. Mallo PL, Díaz DC. Intraoral contact allergy to materials used in dental practice. A critical review. Med Oral. 2003 Nov-Dec;8(5):334-47.
9. Novikov DK, Sergeev YuV, Novikov PD. Lekarstvennaia allergiia [Medicinal allergy]. Moscow, RF: Natsional'naia akademiia mikologii; 2001. 330 р.
10. Brasch J, Geier J, Henseler T. Evaluation of patch test results by use of the reaction index. An analysis of data recorded by the Information Network of Departments of Dermatology (IVDK). Contact Dermatitis. 1995 Dec;33(6):375-80.
11. Kugach VV. Kurs lektsii po aptechnoi tekhnologii lekarstvennykh sredstv [A course of lectures on pharmaceutical technology of medicines]. Vitebsk, RB: VGMU; 2002. 372 р.
