Minina E.S.
Intradermal autoserotherapy as a method of immunorehabilitation of children with atopic bronchial asthma
Education Establishment "Vitebsk State Order of Peoples’ Friendship Medical University", Republic of Belarus
Abstract.
Objectives. To study the influence of intradermal autoserotherapy on the levels of IgE- and IgG-antibodies to the mixt of mites D. pteronyssinus and D. farinae and cytokines (interleukin 10 and transforming growth factor- 1) in children with atopic bronchial asthma.
Material and methods. A course of intradermal autoserotherapy was given to 44 children (31 boys and 13 girls) aged from 6 to 16 years suffering from atopic bronchial asthma with sensitization to house dust mite allergens. The studied group included 5 children with mild intermittent bronchial asthma, 37 children with mild persistent bronchial asthma and 2 children with moderate persistent bronchial asthma. The quantitative analysis of blood serum IgE- and IgG-antibodies to the mixt of mites D. pteronyssinus and D. farinae, interleukin 10, transforming growth factor-o1 was made before the course of autoserotherapy and after it.
Results. There was a statistically significant decrease in the levels of IgE-antibodies to the mixt of mites D. pteronyssinus and D. farinae (p=0,0000001) and transforming growth factor-g1 (p=0,0057) after the course of autoserotherapy. At the same time, the level of transforming growth factor- 1 was significantly higher (p=0,005) in the group of patients with bronchial asthma and concomitant allergic rhinitis compared to the children with bronchial asthma without concomitant allergic rhinitis.
Conclusion. Intradermal autoserotherapy can be used for the optimization of the complex treatment for allergic bronchial asthma in children.
Key words: atopic bronchial asthma, intradermal autoserotherapy, IgE-antibodies, IgG-antibodies, D. pteronyssinus, D. farinae.
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