E.L. Katina, M.R. Konorev
Prognostic factors of the gastric polyps recurrence after performed endoscopic polypectomy
Educational Establishment «Vitebsk State Order of Peoples’ Friendship Medical University», Vitebsk, Republic of Belarus
Abstract.
Objectives. To determine significant prognostic factors reliably affecting the recurrence of gastric polyps after endoscopic polypectomy.
Material and methods. The study of the remote results after performed polypectomy was conducted in terms of up to 2,5 years. The recurrence of gastric polyp revealed during endoscopy was defined as an endpoint. As a result, all patients (n=93) were divided into two groups: the 1st group (n=44) included patients with the recurrence of polyps, the 2nd group (n=49) was composed of patients without the recurrence of polyps. To evaluate any unfavorable prognostic factors that significantly affect the recurrence of gastric polyps binary logistic regression and ROC-analysis were used.
Results. As a result of the conducted study the predictors of poor prognosis significantly affecting the recurrence of gastric polyps were found. They are the number of polyps, polyp size, the presence of erosions in the mucosa of the polyp. The prognostic model of gastric polyps recurrence was developed on the basis of the number of polyps, polyp size, the presence of erosions in the mucosa of the polyp. This model corresponds to the criteria of «excellent» quality model, possesses the sensitivity of 81,82% and specificity of 85,71%.
Conclusions. The constructed model of logistic regression allows to calculate the probability of the recurrence of gastric polyps after performed endoscopic polypectomy.
Key words: polyp, stomach, recurrence.
References
1. Marzhatka Z. Terminologiia, opredeleniia terminov i diagnosticheskie kriterii v endoskopii pishchevaritel'nogo trakta: endoskopiia pishchevaritel'nogo trakta: nomenklatura OMED (Vsemirnoi organizatsii endoskopii pishchevaritel'nogo trakta) [Terminology, definitions of terms and diagnostic criteria in an endoscopy of a digestive tube: endoscopy of a digestive tube: nomenclature of OMED (World organization of an endoscopy of a digestive tube)]: per. s angl. 3-e izd., pererab. i dop. 1-e izd. na rus. iaz. Homburg: Normed Verlag; 1996. 141 р.
2. Aruin LI, Kapuller IL, Isakov VA. Morfologicheskaia diagnostika boleznei zheludka i kishechnika [Morphological diagnosis of stomach diseases and intestine]. Moscow, RF: Triada-Kh; 1998. 496 р.
3. Carmack SW, Genta RM, Graham DY, Lauwers GY. Management of gastric polyps: a pathology based guide for gastroenterologists. Nat Rev Gastroenterol Hepatol. 2009 Jun;6(6):331-41.
4. Morais DJ, Yamanaka A, Zeitune JM, Andreollo NA. Gastric polyps a retrospective analysis of 26,000 digestive endoscopies. Arq Gastroenterol. 2007 Jan-Mar;44(1):14-7.
5. Archimandritis A, Spiliadis C, Tzivras M, Vamvakousis B, Davaris P, Manika Z, Scandalis N. Gastric epithelial polyps: a retrospective endoscopic study of 12974 symptomatic patients. Ital J Gastroenterol. 1996 Sep;28(7):387-90.
6. García-Alonso FJ, Martín-Mateos RM, González Martín JA, Foruny JR, Vázquez-Sequeiros E, Boixeda de Miquel D. Gastric polyps: analysis of endoscopic and histological features in our center. Rev Esp Enferm Dig. 2011 Aug;103(8):416-20.
7. Seifert E, Gail K, Weismüller J. Gastric polypectomy. Long-term results (survey of 23 centres in Germany). Endoscopy. 1983 Jan;15(1):8-11.
8. Gaunt M, Tang T, Walsh S. General Surgery Outpatient Decisions. 2nd ed. London: Radcliffe Publishing Ltd; 2008. 330 р.
9. Erdes SI. Polipy kardioezofageal'nogo perekhoda u detei [Polyps of cardioesophageal transition at children]. Pediatriia. 2006;(6):101–9.
10. Leonov VV, Dontsov IV, Mekhtikhanov ZS, Boiko LA. Rukovodstvo po endoskopii pishchevoda, zheludka i dvenadtsatiperstnoi kishki [Guide to an endoscopy of an esophagus, stomach and duodenum]. Kharkov, Ukraine: Fakt; 2004. 136 р.
11. Faigel DO, Kochman ML, ed. Endoscopic Oncology. Gastrointestinal endoscopy and cancer management. New Jersey: Humana Press Inc; 2006. 380 р.
12. Sotnikov VN, Dubinskaya TK, Esenin DYu, Gavrilov AM, Volova AV. Makroskopicheskaia i morfologicheskaia kharakteristika rezidual'nykh polipov zheludka [Macroscopic and morphological characteristic of residual polyps of a stomach]. Endoskop. khirurgiia. 2010;(5):35–40.
13. Liapunova VN, Nikiforov PA, Brekhov EI, Blokhin AF, Burkov SG, Gribunov YuP. Polipy zheludka: blizhaishie i otdalennye rezul'taty endoskopicheskoi polipektomii i dinamicheskogo nabliudeniia [Stomach polyps: the immediate and remote results of an endoscopic polypectomy and dynamic observation]. Kremlevskaia meditsina. Klin. vestn. 2011;(3):21–4.
14. Jalving M, Koornstra JJ, Wesseling J, Boezen HM, DE Jong S, Kleibeuker JH. Increased risk of fundic gland polyps during long-term proton pump inhibitor therapy. Aliment Pharmacol Ther. 2006 Nov;24(9):1341-8.
15. Vieth M, Stolte M. Fundic Gland Polyps Are Not Induced by Proton Pump Inhibitor. Am J Clin Pathol. 2001 Nov;116(5):716-20.
16. Di Marino AJ, Benjamin SB, ed. Gastrointestinal Disease: An Endoscopic Approach. 2nd ed. New Jersey: SLACK Inc; 2002. 1449 р.
17. Metz CE. Fundamentals of ROC Analysis. In: Bankman IN, editors. Handbook of Medical Imaging. Bellingham WA; 2000. vol 15. p. 751–76.