Rzheussky S.E., Dounar H.G., Kugach V.V.
The study of antimicrobial activity of poviargol
Educational Establishment «Vitebsk State Order of Peoples’ Friendship Medical University», Vitebsk, Republic of Belarus
Vestnik VGMU. 2015;14(6):120-126.
Abstract.
The article presents the results of the study of antimicrobial activity of the pharmaceutical substance Poviargol which is a highly dispersed metallic silver. For the first time the healing properties of this metal were described by Herodotus. Since the fourties of the XX century, when antibiotics were invented the interest in silver began to flag. The new interest in its therapeutical properties is observed now, after it became possible to reduce the size of the metal particles to the nanometre level.
We examined 87 strains of 12 genera of gram-positive and gram-negative microorganisms, and yeast-like fungi using two-fold dilutions method. Both standard museum strains and microorganisms isolated from in-patients of Minsk and Vitebsk hospitals were investigated.
It has been shown, that Poviargol has a broad antimicrobial effect. Its activity is 2-64 times higher than that of Protargol depending on the genus of microorganism.
It has been determined that the minimum bactericidal concentration of Poviargol is 2-16 times higher than the minimum inhibitory concentration. When reducing the microbial load from 109 to 105, the effective concentration of Poviargol becomes 2-4 times smaller.
The amplitude of the minimum inhibitory concentration with respect to the microorganisms of the genus Candida, which characterizes the degree of heterogeneity of the strains made up 0,05%, that indicates similar antifungal activity of Poviargol against different species of yeast-like fungi.
This work was carried out within the framework of the Belarusian Republican Foundation for Fundamental Research.
Key words: Poviargol, silver nanoparticles, antimicrobial effect.
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