DOI: https://doi.org/10.22263/2312-4156.2016.2.77
Odnokozov I.A.*, Khorov O.G.**
The evaluation of vocal fold medialization method with the use of cell autotransplantation of adipocytes in patients with unilateral mobility restriction of the larynx
*Establishment «Gomel Regional Clinical Hospital», Gomel, Republic of Belarus
**Educational Establishment «Grodno State Medical University», Grodno, Republic of Belarus
Vestnik VGMU. 2016;15(2):77-86.
Abstract.
Objectives. To evaluate a new method of vocal fold medialization on the larynx restorative operations in patients with unilateral vocal fold mobility restriction.
Material and methods. In the course of this study the results of vocal fold medialization by the developed and implemented into practice method of autotransplantation of adipocytes into the fixed vocal fold in 33 patients with unilateral vocal fold mobility restriction in one month, three months and long-term period (from 8 months to 13 years) after surgery have been analyzed. To evaluate the results the research in the dynamics of the maximum phonation time, the degree of huskiness, roughness, hoarseness, tremolo has been applied, the glottal function index and the integral index of the degree of life quality satisfaction loss because of the disturbed functions of the larynx have been determined.
Results. According to the obtained data the maximum phonation time and degree of life quality satisfaction improve in the course of time.
The best results on determining the degree of huskiness, roughness, hoarseness and tremolo and the glottal function index have been revealed in three months.
In the long-term period a slight deterioration of these indicators has been revealed. After the operation the prolonged post-operative patients’ care and their rehabilitation have not been required. Granuloma in the early postoperative period, which had been successfully removed was the only complication found.
Conclusions. The developed method of vocal fold medialization with the use of adipocytes cell autotransplantation is effective in treating unilateral vocal fold immobility regardless of its etiology. The method allows to obtain stable morphological and functional effect at short notice.
Key words: vocal fold, surgery, adipocytes, fat, transplantation.
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