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DOI: https://doi.org/10.22263/2312-4156.2016.4.33

Sirotka V.V.
Questions of instrumental diagnosis of reactive arthritis
Educational Establishment «Vitebsk State Order of Peoples’ Friendship Medical University», Vitebsk, Republic of Belarus

Vestnik VGMU. 2016;15(4):33-39.

Abstract.
Objectives. To study the characteristics and nature of the joints lesions in patients  with reactive arthritis using magnetic resonance imaging (MRI) and ultrasonography (USG) of the joints, to assess their informativeness.
Material and methods. We examined 56 patients with ReA, whose average age was 34 years (31-42), and whose median duration of arthritis made up 1 year (from 0,3 to 3,25). All patients underwent comprehensive clinical, laboratory and instrumental examination. The study of the inflamed joints included MRI in the Т1W, Т2W, STIR modes, multiple-scale dynamic ultrasound examination in B-mode and X-ray examination.
Results. When performing MRI of the affected joints the inflamed entheses (thickening, microfractured fibers, the appearance of the sites of the decreased and increased density), the presence beneath them of local osteitis  and erosive defect of the vertebral end bone plate were clearly visualized. When conducting ultrasound investigation of the inflamed joint nonlinear boundary defect of the cortical bone layer with a hyperechogenic contour in the places of the inflamed enthesis fixation with reduced echogenicity due to the acute inflammation with unechogenic areas – microtears was determined. Articular surface of the bones in the places of the synovial fixation was with a clearly hyperechogenic, smooth contour, and the synovium without any pathological vascularization and focal thickening. When conducting the research in all affected joints of the patients with this pathology we revealed positive «pain test» under ultrasound control.
Conclusions. We have found that ultrasound is not inferior to MRI with regard to its  informativeness in the assessment of the nature and extent of the pathological process in the tendinous-ligamentous apparatus and tissues surrounding the joints. Ultrasonic criteria of the joints lesions in ReA are: enthesitis, osteitis of the vertebral end plate of the bone under the inflamed enthesis, inflammation erosions in the places of the inflamed entheses insertion, paraentheseal edema and / or exudation, positive «pain test» on palpation of the affected enthesis under ultrasound control.
Key words: reactive arthritis, enthesitis, osteitis, erosion.

References

1. Colmegna I, Cuchacovich R, Espinoza LR. HLA-B27-Associated Reactive Arthritis: pathogenetic and clinical considerations. Clin Microbiol Rev. 2004 Apr;17(2):348-69.
2. Vähämiko S, Penttinen MA, Granfors K. Aetiology and pathogenesis of reactive arthritis: role of non-antigen-presenting effects of HLA-B27. Arthritis Res Ther. 2005;7(4):136-41.
3. Glazunov AV, Panina IA, Adzhigaytkanova SK, Glazunov PA. Reaktivnyi artrit: kriterii diagnoza i podkhod k etiotropnoi terapii [Reactive arthritis: criteria of the diagnosis and approach to causal treatment]. Klinich Gerontologiia. 2008;14(2):41-6.
4. Kwiatkowska B, Filipowicz-Sosnowska A. Reactive arthritis. Pol Arch Med Wewn. 2009 Jan-Feb;119(1-2):60-5.
5. Meyer A, Chatelus E, Wendling D, Berthelot JM, Dernis E, Houvenagel E et al. Safety and efficacy of anti-tumor necrosis factor H therapy in ten patients with recent-onset refractory reactive arthritis. Arthritis Rheum. 2011 May;63(5):1274-80.
6. Curry JA, Riddle MS, Gormley RP, Tribble DR, Porter CK. The epidemiology of infectious gastroenteritis related reactive arthritis in U.S. military personnel: a case-control study. BMC Infect Dis. 2010 Sep;10:266.
7. Scheel AK, Hermann K-GA, Ohrndorf S, Werner C, Schirmer C, Detert J et al. Prospective 7 year follow up imaging study comparing radiography, ultrasonography, and magnetic resonance imaging in rheumatoid arthritis finger joints. Ann Rheum Dis. 2006;65(5):595-600.
8. Kazakova TV, Rashid MA, Shostak NA, Karpova NYu. Reaktivnyi artrit: klinika, diagnostika i lechenie [Reactive arthritis: clinic, diagnostics and treatment]. Lecheb Delo. 2010;(1):11-22.
9. Yushchuk ND, Tseneva GYa, Burgasova OL. Etiologicheskie i patogeneticheskie aspekty reaktivnykh artritov [Etiological and pathogenetic aspects of reactive arthritises]. Epidemiologiia i Infektsion Bolezni. 2009;(5):49-52.
10. Eustice C. Diagnosing Reactive Arthritis. Verywell.com [Internet] 2010 [cited 2016 Aug 25]. Available from: http://arthritis.about.com/cs/reiters/a/reactivediag.htm.
11. Ostergaard M, Edmonds J, McQueen F, Peterfy C, Lassere M, Ejbjerg B et al. An introduction to the EULAR-OMERACT rheumatoid arthritis MRI reference image atlas. Ann Rheum Dis. 2005 Feb;64(Suppl 1):i3-i7.
12. Nasonova VA. Nasonov EL, Alekperov RT, Alekseeva LI, Ananiyeva LP, Baranov AA, Barskova VG, Nasonova VA, red, Nasonov EL, red. Ratsional'naia farmakoterapiia revmaticheskikh zabolevanii [Rational pharmacotherapy of rheumatic diseases]: ruk dlia prakt vrachei. Moscow, RF: Literra; 2003. 507 р.
13. Rohekar S, Pope J. Epidemiologic approaches to infection and immunity: the case of reactive arthritis. Curr Opin Rheumatol. 2009 Jul;21(4):386-90.

Information about authors:
Sirotka V.V. – Candidate of Medical Sciences, associate professor of the Chair of Internal Medicine No. 1, Educational Establishment «Vitebsk State Order of Peoples’ Friendship Medical University».

Correspondence address: Republic of Belarus, 210023, Vitebsk, 27 Frunze ave., Educational Establishment «Vitebsk State Order of Peoples’ Friendship Medical University», Chair of Internal Medicine No. 1. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. –Sirotka Volha V.

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