DOI: https://doi.org/10.22263/2312-4156.2016.4.40
Semenov D.M.
D-lactate as a marker of dysbiotic and inflammatory diseases of the lower genital tract in women
Educational Establishment «Vitebsk State Order of Peoples’ Friendship Medical University», Vitebsk, Republic of Belarus
Vestnik VGMU. 2016;15(4):40-45.
Abstract.
Objectives. To evaluate the possibility of D-lactate investigation in the diagnosing and assessment of treatment efficacy in case of inflammatory and dysbiotic states of the lower genital tract.
Material and methods. D-lactate concentration has been studied in the material taken from the vagina in 26 women with bacterial vaginosis, 21 women with nonspecific vaginitis, 23 women with normal vaginal biocenosis.
Results. The etiologic component of the lower genital tract inflammation (vaginitis) in women of the reproductive age in the majority of cases is represented by a nonspecific bacterial flora: Ent. faecalis (38% of the total number of cases of positive cultures), St. epidermidis (31,7%), Str. haemalyticus (19%), U. Urealyticum (11,3%). The median of D-lactate concentration in the material obtained from the posterior vaginal vault in women without any signs of inflammation and with normal microbiocenosis is 24,8 (22,6; 31,2) imol / (l×g). The median of D-lactate concentration in female patients with the diagnosed vaginal inflammation and bacterial vaginosis, regardless of the bacterial agent causing the inflammatory process, is statistically significantly lower (p=0,0001) and makes up 14,1 (11,6; 14,7) imol / (l×g). The value of D-lactate amounting to 18,14 gmol / (l×g) is the point of the diagnostic division of the pathological process and normal microbiocenosis, sensitivity and specificity being 98,4% and 98,1%, respectively. High sensitivity and specificity of the test for determining the level of D-lactate in the material obtained from the vaginal vaults enable its usage as a universal criterion of the presence of an inflammation of the bacterial etiology and the state of the vaginal ecosystem.
Key words: bacterial vaginosis, vaginitis, D-lactate.
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Information about authors:
Semenov D.M. – Doctor of Medical Sciences, associate professor of the Chair of Obstetrics & Gynecology, Educational Establishment «Vitebsk State Order of Peoples’ Friendship Medical University».
Correspondence address: Republic of Belarus, 210023, Vitebsk, 27 Frunze ave., Educational Establishment «Vitebsk State Order of Peoples’ Friendship Medical University», Chair of Obstetrics & Gynecology. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Semenov Dmitry M.
