DOI: https://doi.org/10.22263/2312-4156.2016.6.41
Gorodetskaya I.V., Gusakova E.A., Evdokimova O.V.
Peripheral mechanisms of the stress-protective effect of iodine-containing thyroid hormones
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2016;15(6):41-53.
Abstract.
In experiments on 240 adult mongrel white male rats weighing 200-250 g the effect of iodine-containing thyroid hormones on the trypsin-like proteolytic enzyme activity in the liver and the blood and on the expression of the early response genes in the myocardium under stress has been studied. Emotional stress, characterized by changes in the blood serum levels of thyroid hormones, causes the increase in the activity of trypsin-like proteinases and stimulates the expression of the c-fos and c-jun genes. The administration of mercazolil (25 mg / kg in 1% starch paste during 20 days), accompanied by a decrease in serum concentration of iodine-containing thyroid hormones under stress, provokes a more pronounced in comparison with euthyroid animals activation of proteolysis in the liver and the blood and «switches off» the response of c-fos and c-jun genes in the myocardium. L-thyroxin, administered at doses provisionally called small (1,5-3 µg / kg in 1% starch paste during 28 days), limits the change in serum levels of iodine-containing thyroid hormones, the increase of trypsin-like proteinases activity and promotes a greater stimulation of early response genes expression under stress. Тhere is a strong correlation between the serum level of iodine-containing thyroid hormones on the one hand, and trypsin-like activity in the liver and the blood, the expression of c-fos and c-jun genes in the myocardium, on the other hand. The obtained results demonstrate the new local mechanisms of the antistress effect of iodine-containing thyroid hormones – the minimization of lysosomal dysfunction and stimulation of the early response genes expression.
Key words: iodine-containing thyroid hormones, trypsin-like proteolytic enzymes, early genes, stress.
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Information about authors:
Gorodetskaya I.V. – Doctor of Medical Sciences, professor of the Chair of Normal Physiology, Vitebsk State Order of Peoples’ Friendship Medical University;
Gusakova E.A. – Candidate of Biological Sciences, associate professor of the Chair of General, Physical and Colloid Chemistry, Vitebsk State Order of Peoples’ Friendship Medical University;
Evdokimova O.V. – Candidate of Medical Sciences, associate professor of the Chair of Normal Physiology, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210023, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Normal Physiology. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Gorodetskaya Irina V.
