DOI: https://doi.org/10.22263/2312-4156.2017.1.23
Gorodetskaya I.V., Masyuk N.Y.
The influence of iodine-containing thyroid hormones on the resistance of the enamel and dentin to caries, stress and their combination
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2017;16(1):23-32.
Abstract.
Objectives. To study the effect of iodine-containing thyroid hormones on the resistance of the enamel and dentin to the carious lesion under stress.
Material and methods. The experiments were performed on 390 mongrel male rats maintained on the cariogenic diet of Stefan, under the conditions of crowding stress (40 animals were in one cage during the first 30 days, 30 animals-during the next 30 days) and under those of the combination of both influences. Hypothyroidism was caused by the intragastric administration of mercazolil in 1% starch paste in the dose of 25 mg / kg during 30 days, and then in the half dose till the end of the experiment. L-thyroxin was injected in the similar way in the increasing doses from 1,5 to 3,0 mcg / kg during 28 days, then in the dose of 1,5 mcg / kg till the 60th day. The general resistance of an organism was characterized by a change of the relative weight of stress-sensitive organs, the state of the gastric mucosa. The activity of the caries process was evaluated by its prevalence, frequency, severity and depth.
Results. It has been found that experimental hypothyroidism reduces the body’s resistance to stress and exacerbates the caries process in animals kept in congested conditions, on the cariogenic diet and under the conditions of these influences combination. The small doses of L-thyroxin stimulate the adaptive capacities of the body, limit the intensity of dental caries caused by the use of the cariogenic diet, isolated and combined with the congested keeping of rats, and prevent its development under stress.
Conclusions. Therefore, the resistance of dental hard tissues to the cariogenic impact depends on the thyroid status of the organism, which proves the necessity for its studying and correction in patients with the high activity of the caries process and in persons subject to frequent stress influences.
Key words: iodine-containing thyroid hormones, stress, caries resistance.
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Information about authors:
Gorodetskaya I.V. – Doctor of Medical Sciences, professor of the Chair of Normal Physiology, Vitebsk State Order of Peoples’ Friendship Medical University;
Masyuk N.Y. – postgraduate of the Chair of Normal Physiology, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210023, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Normal Physiology. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Irina V. Gorodetskaya.
