DOI: https://doi.org/10.22263/2312-4156.2017.1.80
Tikhonovskaya I.V., Lesnichaya O.V.
Pathomorphological manifestations of alopecia areata
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2017;16(1):80-87.
Abstract.
Objectives. To investigate the pathomorphological manifestations of alopecia areata.
Material and methods. Biopsy specimens from 10 patients with various forms of alopecia areata were analyzed.
Results. Peribulbar infiltrates of the «swarm of bees» type with different density were determined in all samples. Some of them spread to the higher parts of the follicle (in 30% of cases). The increased number of katagen and telogen hair was determined in 50% of patients, trichomalacia in 30% of the samples studied, the miniaturization of hair follicles in 20% of cases. Isolated eosinophils in the infiltrate were determined in 20% of cases, plasma cells in 10%, 10% of the lymph cells were localized in the bulb of the follicle. Vacuolar degeneration of the bulbar epithelium and hyalinized vitreous membrane were determined in 10% of cases.
Conclusions. The study requires a much larger number of histological samples of alopecia areata to complement its histological and immunohistochemical signs which will enable its differentiation from other types of noncicatrical alopecias, the determination of new pathogenetic processes and development of new treatment methods.
Key words: alopecia areata, pathomorphology, peribulbar infiltrates.
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Information about authors:
Tikhonovskaya I.V. – Candidate of Medical Sciences, associate professor of the Chair of Dermatovenerology, Vitebsk State Order of Peoples’ Friendship Medical University;
Lesnichaya O.V. – Candidate of Medical Sciences, associate professor of the Chair of Pathologic Anatomy, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210023, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Dermatovenerology. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Irina V. Tikhonovskaya.
