DOI: https://doi.org/10.22263/2312-4156.2017.2.26
Kirpichenka A.A., Kim I.Y.
Psychobiotics: can gut microbiota influence host’s mental health?
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2017;16(1):26-42.
Abstract.
Despite the fact that the beginning of the study of the gut-brain and microflora-host relationships was initiated by the scientists on the borderline between the 19th and the 20th centuries, the theory considering the microbiota as one of the main determinants of health, including the mental one, has been developed only these days. The study of the processes occurring on the microbiome-gut-brain axis offers the challenge for the application of this new pathogenetically oriented method in the complex treatment of depressive and anxiety disorders.
In the present review the current notions of the gut microbiota, its composition and functions are briefly considered; the available scientific literature data on the influence of the microbiota on the development and course of anxiety and depression disorders are systematized; the results of the first clinical trials of medicines called «psychobiotics» are presented; the main pathogenetic mechanisms of depression and anxiety being the target for anxiolytic and antidepressant effects of psychobiotics are outlined.
Key words: intestinal microbiome, probiotics, depression, anxiety.
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Information about authors:
Kirpichenka A.A. – Doctor of Medical Sciences, associate professor, head of the Chair of Psychiatry & Narcology, Vitebsk State Order of Peoples’ Friendship Medical University;
Kim I.Y. – MSc (Medicine) student of the Chair of Psychiatry & Narcology, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210023, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Psychiatry & Narcology. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Andrey A. Kirpichenka.
