DOI: https://doi.org/10.22263/2312-4156.2017.5.117
Karpuk I.Y., Novikov D.K., Sakharuk N.A.
Immunotherapy for prosthetic stomatitis associated with candidiasis
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2017;16(5):117-126.
Abstract.
Objectives. To establish the frequency of immunodeficiency in persons suffering from prosthetic stomatitis associated with oral cavity candidiasis and to develop the method of its treatment.
Material and methods. The examination of 35 patients aged from 52 to 71 years with complaints of prosthetic stomatitis (PS) and 20 volunteers without PS comparable with regard to orthopedic constructions was conducted.
We offered the scheme of therapy combining traditional treatment with the use of sodium nucleinat for immunocorrection and «Human immunoglobulin normal» which we diluted with physiological solution at a ratio of 1:20 for irrigation, instillations, applications and mouth rinsing for a purpose of candidiasis biofilm destruction. Patients took sodium nucleinat immunomodulator orally after meals. The single dose made up 1-2 g taken 2-4 times a day during 1 month. The patients used the «Human immunoglobulin normal» preparation during 2 weeks 3 times a day after meals as follows: opened an ampoule, its contents diluted with sterile physiological solution at a ratio of 1:20 and rinsed the oral cavity during 2-3 minutes, then spitted out.
Results. It has been revealed that in patients with PS associated with candidiasis the signs of secondary immunodeficiency both of general and local link of immunity were observed.
Sodium nucleinat and immunoglobulin immunocorrection improves the indices of the immune status of the patients with prosthetic candidiasis stomatitis: T-and B lymphocytes composition, the indices of phagocytosis and immunoglobulins of the blood and oral liquid.
Conclusions. The oral application of sodium nucleinat and immunoglobulin by patients with prosthetic stomatitis associated with candidiasis as a part of the traditional therapy improved their cure in 30 days.
Key words: prosthetic stomatitis, candidiasis, immunodeficiency, treatment.
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Information about authors:
Karpuk I.Y. – Candidate of Medical Sciences, associate professor, doctoral candidate of the Сhair of Clinical Immunology & Allergology with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
Novikov D.K. – Doctor of Medical Sciences, professor, head of the Сhair of Clinical Immunology & Allergology with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
Sakharuk N.A. - Candidate of Medical Sciences, associate professor of the Сhair of Restorative Dentistry, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210029, Vitebsk, 66 Pravdy str., 112. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Ivan Y. Karpuk.
