DOI: https://doi.org/10.22263/2312-4156.2017.5.68
Khadzkou Y.K., Balaboshka K.B.
The results of combined aminocaproic acid use in total knee joint replacement
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2017;16(5):68-74.
Abstract.
Objectives. To evaluate the effectiveness of combined aminocaproic acid use for reducing the perioperative blood loss in primary total knee joint replacement.
Material and methods. The method of combined aminocaproic acid injection was developed and applied in the treatment of 122 patients, who had undergone total knee joint replacement for the 3rd – the 4th stages of gonarthrosis. This method includes single intravenous introduction of 5% aminocaproic acid in the dose of 100 mg/kg of the body mass as well as periarticular and intra-articular injections after the installation of all components of endoprosthesis. Such indices as hemoglobin concentration, erythrocytes count, hematocrit were determined before the operation and within 1, 5 days of the postoperative period.
Results. The average value of blood count before the operation made up: 140±13 g/l for hemoglobin, 4,7±0,42×1012/l for erythrocytes, 42,2±4,2 for hematocrit (Me±SD). On the 5th day after the operation blood count constituted: 116,5±15 g/l for hemoglobin, 3,9±0,48×1012/l for erythrocytes, 34,9±4,6 for hematocrit (Me±SD). None of the cases required donor blood components transfusion. There were no complications associated with the aminocaproic acid usage.
Conclusions. The combined use of aminocaproic acid proved to be an efficient and practical method of treating patients with degenerative dystrophic diseases of the knee joint by eliminating the need for surgical blood transfusion in the total knee joint replacement as well as by decreasing the reimbursement of expenses for surgical procedures.
Key words: knee joint replacement, blood loss, fibrinolysis inhibitors, aminocaproic acid, blood transfusion, economic efficiency, surgical intervention.
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Information about authors:
Khadzkou Y.K. – teacher-trainee of the Chair of Traumatology, Orthopedics & Military Surgery, Vitebsk State Order of Peoples’ Friendship Medical University;
Balaboshka K.B. – Candidate of Medical Sciences, associate professor, head of the Chair of Traumatology, Orthopedics & Military Surgery, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210023, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Traumatology, Orthopedics & Military Surgery. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Yauheni K. Khadzkou.
