Menu

A+ A A-

Download article

DOI: https://doi.org/10.22263/2312-4156.2017.5.7

Shchastny A.T.
Modern principles of chronic pancreatitis diagnosing and treatment
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus

Vestnik VGMU. 2017;16(5):7-20.

Abstract.
Chronic pancreatitis is one of the leading diseases in gastroenterology, it makes up 8-9% in the structure of gastrointestinal tract organs morbidity, and in that of general pathology – 0,5%.
The process of fibrotic transformation with gradual replacement of pancreatic parenchyma leads to exocrine insufficiency and maldigestion, loss of weight, and at an advanced stage to diabetes mellitus. In addition to exocrine and endocrine dysfunction such complications as stenosis of the duodenum, common bile duct and pancreatic duct develop. Long progression of the disease results in fatal outcome in 20,8 – 30% of patients with chronic pancreatitis.
Pain syndrome is the most common indication for operation with resection or drainage variants. The advantage of simple drainage operation is maximum preservation of the pancreas tissue. However, fibrously changed tissues are not removed during drainage operations, especially those located in the head of the pancreas, which leads to the unsatisfactory outcomes in a considerable number of patients and requires the performance of resection interventions. There is no standard operation that is used for the elimination of pain and complications in chronic pancreatitis and meets  the requirements set to an ideal one. Firstly, none of the operations eliminates the structural disturbances of the pancreas and the complications associated with chronic pancreatitis. Secondly, the choice of an operation is difficult for those patients, in whom pain is the only symptom of the disease.
Key words: chronic pancreatitis, pancreas, minimally invasive surgery, pancreatic cysts, laparoscopic techniques.

References

1. Danilov MV, Fedorov VD. Pancreas surgery: ruk dlia vrachei. Moscow, RF: Meditsina; 1995. 512 р. (In Russ.) 
2. Kubyshkin VA, Kozlov IA, Vishnevskiy VA i dr. The choice of a way of surgical treatment of chronic pancreatitis with a primary lesion of a head of a pancreas. Annaly Khirurg Gepatologii. 2008;13(3):172. (In Russ.)
3. Otsuki M, Tashiro M. Chronic pancreatitis and pancreatic cancer, lifestyle-related diseases. Intern Med. 2007;46(2):109-13.
4. Pedersen NT, Worning H. Chronic pancreatitis. Scand J Gastroenterol Suppl. 1996;216:52-8.
5. Lo RS, Singh RK, Austin AS, Freeman JG. Autoimmune pancreatitis presenting as a pancreatic mass mimicking malignancy. Singapore Med J. 2011 Apr;52(4):e79-81.
6. Hartel M, Tempia-Caliera AA, Wente MN, Z'graggen K, Friess H, Buchler MW. Evidence-based surgery in chronic pancreatitis. Langenbecks Arch Surg. 2003;388(2):132-9.
7. Lankisch MR, Imoto M, Layer P, DiMagno EP. The effect of small amounts of alcohol on the clinical course of chronic pancreatitis. Mayo Clin Proc. 2001 Mar;76(3):242-51.
8. Rothenbacher D, Löw M, Hardt PD, Klör HU, Ziegler H, Brenner H. Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based study. Scand J Gastroenterol. 2005 Jun;40(6):697-704.
9. Sarner M, Cotto PB. Classification of pancreatitis. Gut. 1984 Jul;25(7):756-9.
10. Buechler MW, Friess H, Uhl W, Malfertheiner P. Chronic pancreatitis: Novel concepts in biology and therapy. United Kingdom: John Wiley and Sons Ltd; 2002. 614 p.
11. Gubergrits NB. Pancreatic pain: how to help the patient. Moscow, RF: Medpraktika-M; 2005. 176 р. (In Russ.)
12. Büchler MW, Uhl W, Malfertheiner P. Pancreas-erkrankungen. Basel, Switzerland: Karger; 2003. 218 p.
13. Prinz RA, Aranha GV, Greenlee HB, Kruss DM. Common duct obstruction in patients with intractable pain of chronic pancreatitis. Am Surg. 1982 Aug;48(8):373-7.
14. Malfertheiner P, Büchler M, Stanescu A, Ditschuneit H. Pancreatic morphology and function in relationship to pain in chronic pancreatitis. Int J Pancreatol. 1987 Feb;2(1):59-66.
15. Becker V, Mischke U. Groove pancreatitis. Int J Pancreatol. 1991;10:173-82.
16. Evans JD, Morton DG, Neoptolemos JP. Chronic pancreatitis and pancreatic carcinoma. Postgrad Med J. 1997 Sep;73(863):543-8.
17. Bachmann K, Izbicki JR, Yekebas EF. Chronic pancreatitis: modern surgical management. Langenbeck's Arch Surg. 2011 Feb;396(2):139-49.
18. Köninger J, Friess H, Müller M, Büchler MW. Duodenum preserving pancreatic head resection in the treatment of chronic pancreatitis. Rocz Akad Med Bialymst. 2004;49:53-60.
19. Shen Q, Xue HZ, Jiang QF, Wang YD. Duodenum-preserving pancreatic head resection in treating patients with chronic pancreatitis. Zhonghua Yi Xue Za Zhi. 2010 Nov;90(44):3127-30.
20. Izbicki JR, Bloechle C, Knoefel WT, Kuechler T, Binmoeller KF, Broelsch CE. Duodenum-preserving resection of the head of the pancreas in chronic pancreatitis. A prospective, randomized trial. Ann Surg. 1995 Apr;221(4):350-8.
21. Frey CF, Smith GJ. Description and rationale of a new operation for chronic pancreatitis. Pancreas. 1987;2(6):701-7.
22. Beger HG, Matsuno S, Cameron JL. Diseases of the pancreas, current surgical therapy Berlin-Heidelberg: Springer; 2008. 919 p.
23. Frey CF, Mayer KL. Comparison of local resection of the head of the pancreas combined with longitudinal pancreaticojejunostomy frey procedure) and duodenum-preserving resection of the pancreatic head (beger procedure). World J Surg. 2003 Nov;27(11):1217-30.
24. Müller MW, Friess H, Martin DJ, Hinz U, Dahmen R, Büchler MW. Long-term follow-up of a randomized clinical trial comparing Beger with pylorus-preserving Whipple procedure for chronic pancreatitis. Br J Surg. 2008 Mar;95(3):350-6. doi: http://dx.doi.org/10.1002/bjs.5960
25. Gloor B, Friess H, Uhl W, Büchler MW. A modified technique of the Beger and Frey procedure in patients with chronic pancreatitis. Dig Surg. 2001;18(1):21-5. doi: http://dx.doi.org/50092
26. Kimura W, Muto T, Makuuchi M, Nagai H. Subtotal resection of the head of the pancreas preserving duodenum and vessels of pancreatic arcade. Hepatogastroenterology. 1996 Nov-Dec;43(12):1438-41.
27. Imaizumi T, Hanyu F, Toshiaki MS, Harada N, Hatori T. Clinical experience with duodenum-preserving total resection of the head of the pancreas with pancreaticocholedochoduodenostomy. J Hepatobiliary Pancreat Surg. 1995 Mar;2(1):38-44.
28. Takada T, Yasuda H, Uchiyama K, Hasegawa H, Iwagaki T, Yamakawa Y. Complete duodenum-preserving resection of the head of the pancreas with preserving biliary tract / T. Takada [et al.] // J. Hepatobiliary Pancreat. Surg. – 1995 Mar. – Vol. 2, N 1. – P. 32–37.
29. D’Egidio A, Schein M. Pancreatic pseudocysts: a proposed classification and its management implications. Br J Surg. 1991 Aug;78(8):981-4.
30. Warshaw AL, Rattner DW. Timing of surgical drainage for pancreatic pseudocyst. Clinical and chemical criteria. Ann Surg. 1985 Dec;202(6):720-4.
31. Shchastny AT, Shturich IP, Syatkovskiy AR. Double drainage at treatment of larger pseudocysts of a pancreas. Novosti Khirurgii. 2010;18(6):133-8. (In Russ.)
32. Shchastny AT. Method of «a double drainage» in treatment of larger pseudocysts of a pancreas. Voen Meditsina. 2010;(1):65-9. (In Russ.)
33. Shchastny A, Siatcouski A, Panko S. Laparoscopic surgery for the treatment of sequelae of pancreatitis - 18 cases report and a review of the literature. Studia Medyczne. 2011;23(3):29-33.

Information about authors:
Shchastny A.T. – Doctor of Medical Sciences, rector, professor of the Chair of Surgery of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University.

Correspondence address: Republic of Belarus, 210023, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Surgery of the Faculty for Advanced Training & Retraining. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Anatoly T. Shchastny.
                                                                   

Поиск по сайту