DOI: https://doi.org/10.22263/2312-4156.2017.5.84
Vardanyan A.V.1, Karapetyan Q.V.1, Alieva M.B.2
Amyloid and tau brain pathology in hyppocampal neurons on the activation of entorhinal cortex on the model of Alzheimer’s disease and in the conditions of protection with galarmin
1L.A. Orbeli Institute of Physiology of the Armenian National Academy of Sciences, Erevan, Republic of Armenia
2West Kazakhstan State Medical University named after Marat Ospanov, Aktobe, Kazakhstan
Vestnik VGMU. 2017;16(5):84-89.
Abstract.
The research was conducted on the model of Alzheimer’s disease (AD) and in the conditions of protection with galarmin. The comparative analysis of the impulse activity of the single hippocampal neurons on high-frequency stimulation of the entorhinal cortex on the AD model (205 cells, n=2) and in the conditions with the galarmin protection (73 cells, n=2) on the 12th week of animals keeping was made. In the present experiments, on the AD model and in the combination with the galarmin protection after 12 weeks, the diversion of the activity of single hippocampal neurons on high-frequency stimulation of the entorhinal cortex and hippocampus on-line selection and program mathematical analysis revealed the formation of excitative and depressor responses in the form of TD and TP combined into one- (TD PDD, TP PTP) and multidirectional (TD PTP, TP PDD) sequence. The results of the studies on the use of proline enriched peptides allow us to consider galarmin or PRP-1 as an immunomodulator-neurohormone and a broad-spectrum protector.
Key words: Alzheimer’s disease, entorhinal cortex, galarmin.
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Information about authors:
Vardanyan A.V. – Candidate of Biological Sciences, neuroendocrinologist, research officer, L.A. Orbeli Institute of Physiology of the Armenian National Academy of Sciences;
Karapetyan K.V. – associate research officer, L.A. Orbeli Institute of Physiology of the Armenian National Academy of Sciences;
Alieva M.B. – the first-year clinical resident (speciality «General neuropathology»), West Kazakhstan State Medical University named after Marat Ospanov.
Correspondence address: Republic of Armenia, 0028, Erevan, L.A. Orbeli Institute of Physiology of the Armenian National Academy of Sciences, the Laboratory «Central nervous system function compensation physiology». E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра., +374 94 92 43 66 – Anahit V. Vardanyan.
