DOI: https://doi.org/10.22263/2312-4156.2017.6.51
Gostishchev V.K.1, Kupchenko A.M.2, Kosinets V.A.2
Antibacterial therapy in the structure of medicines used in the treatment of patients with generalized peritonitis
1I.M. Sechenov First Moscow State Medical University, Moscow, Russia
2Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2017;16(6):51-60.
Abstract.
Objectives. To аnalyze the structure and the administration frequency of medicines, as well as to evaluate the significance of antibacterial therapy in complex treatment of patients with generalized peritonitis.
Material and methods. The structure and administration frequency of medicines in complex treatment of 319 patients with generalized peritonitis were analyzed. Data collection was carried out on the basis of medical documentation. We recorded the medicines used that were prescribed in accordance with the standards of diagnosing and treatment of patients with acute surgical diseases of the abdominal cavity. In this work international АТС classification of medicines was used.
Results. From 2007 to 2016 in 319 patients with generalized peritonitis 3957 courses of medicines administrations were provided, during which 37 names of medicines were used. All of them were included in 5 major groups applied for the treatment of organs and systems: medicines, that influence hemopoiesis and the blood (B) – 41,93% of all administrations; antimicrobial medicines for systemic use (J) – 25,90% of all prescriptions; medicines, that influence the digestive tract and metabolism (A) – 13,04% of all administrations; medicines, that influence the nervous system (N) – 12,74% of all prescriptions; medicines, that influence the osteomuscular system (M) – 6,39% of all administrations. Antimicrobial medicines for systemic use were prescribed to all patients with generalized peritonitis. Among individual antimicrobic preparations metronidazole (94,1% of patients), ciprofloxacin (77,7% of patients), cefotaxime (74,3% of patients) were prescribed most frequently. The most costly group was that of antimicrobial medicines for systemic use, the share of which made up more than 50% of the expenses, as well as the group of plasma substitution and perfused solutions (В05) and agents influencing the system of blood and hemopoiesis (B01), that amounted to about 40% of the costs.
Conclusions. Pharmacoeconomic analysis allows to evaluate the actual practice of medicines consumption in complex treatment of patients with generalized peritonitis, clinical and economic soundness of their prescription, which identifies the ways to optimize pharmacotherapy.
Key words: generalized peritonitis, antibacterial therapy, medicines.
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Information about authors:
Gostishchev V.K. – Doctor of Medical Sciences, academician of the Russian Academy of Sciences, professor, head of the Chair of General Surgery, I.M. Sechenov First Moscow State Medical University;
Kupchenko A.M. – senior lecturer of the Chair of Operative Surgery & Topographic Anatomy, Vitebsk State Order of Peoples’ Friendship Medical University;
Kosinets V.A. – Doctor of Medical Sciences, professor of the Chair of Hospital Surgery with the courses of Urology & Pediatric Surgery, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210023, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Operative Surgery & Topographic Anatomy. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Anna M. Kupchenko.
