DOI: https://doi.org/10.22263/2312-4156.2017.6.61
Sushkov S.A.1, Nebylitsin Y.S.2, Pasevich D.M.1, Demidov S.I.1
The correction of endothelium functional state disturbances in patients with post-thrombotic syndrome of the lower extremities
1Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
2Vitebsk State Medical University Clinic, Vitebsk, Republic of Belarus
Vestnik VGMU. 2017;16(6):61-71.
Abstract.
Objectives. To optimize the approaches to the treatment of patients with post-thrombotic syndrome of the lower extremities veins by affecting the functional state of the blood vessels endothelium.
Material and methods. 35 patients (males – 24, females – 11) with post-thrombotic syndrome (PTS) were included in the study of the efficacy and results of treatment of the developed method. Depending on the provided treatment, patients were divided into two groups. In the first group, standard treatment regimen was used: anti-inflammatory drugs, antiaggregants, elastic compression. In the second group, the following drugs were included in the complex treatment regimen: phlebotropic drug – micronized purified flavonoid fraction – 500 mg (including diosmin (90%) – 450 mg and flavonoids in terms of hesperidin (10%) – 50 mg) (in form of the drug «Detraven») – 1000 mg per day during 30 days, angioprotector – pentoxifylline 0,08% – 250 ml during 10 days intravenously.
Results. It has been established that the use in the complex treatment of drugs: pentoxifylline, phlebotropic drug – micronized purified flavonoid fraction – 500 mg (including diosmin (90%) – 450 mg and flavonoids in terms of hesperidin (10%) – 50 mg) – 1000 mg a day for the purpose of correcting the functional state of the endothelium is pathogenetically grounded. An increase in endothelin-1 plasma concentration, an increase in interleukin-4 level, a decrease in the number of circulating endothelial cells, nitrates and nitrites content in the blood plasma, and the interleukin-6 level were observed. Regression of clinical manifestations of the disease was also noticed.
Conclusions. The conducted study confirmed the effectiveness of the use of drugs restoring the functional state of the endothelium in the complex treatment of patients with post-thrombotic syndrome of the veins of the lower extremities.
Key words: post-thrombotic syndrome, endothelial dysfunction, S-Nitrosylation.
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Information about authors:
Sushkov S.A. – Candidate of Medical Sciences, associate professor, pro-rector for scientific research work, Vitebsk State Order of Peoples’ Friendship Medical University;
Nebylitsin Y.S. – Candidate of Medical Sciences, associate professor, head of the Department of Plastic Surgery & Cosmetology, Vitebsk State Medical University Clinic;
Pasevich D.M. – lecturer of the Chair of General Surgery, Vitebsk State Order of Peoples’ Friendship Medical University;
Demidov S.I. – lecturer of the Chair of General Surgery, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210039, 210039, Vitebsk, 20 Pobedy ave., Vitebsk State Medical University Clinic, the Department of Plastic Surgery & Cosmetology. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Yuriy S. Nebylitsin.
