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Shakavets N.V.1, Likhorad Y.V.1, Zhernasek N.A.2, Shabunya Р.S.3
The state of dental hard tissues and physicochemical properties of the saliva in children with phenylketonuria
1Belarussian State Medical University, Minsk, Republic of Belarus
2Joint Venture «NORDIN» Ltd. Medical Center, Minsk, Republic of Belarus
3Institute of Bioorganic Chemistry of the Belarusian National Academy of Sciences, Minsk, Republic of Belarus

Vestnik VGMU. 2017;16(6):85-91.

Objectives. To assess the status of teeth and some laboratory parameters of the saliva in children with phenylketonuria, to analyze the mineral composition of the tooth enamel and saliva in this category of patients.
Material and methods. The incidence of tooth decay, the physicochemical properties of the saliva (pH, buffer capacity, the concentration of calcium and phosphorus), the mineral composition of the enamel as well as the state of the immune system of the oral cavity were evaluated in 97 children with phenylketonuria and 97 practically healthy children aged from 2 to 18 years. The data were analyzed by means of the program Statistica 10.0 using the χ2-test and the t- Student test.
Results. The state of dental hard tissues as well as physicochemical properties of the saliva were significantly worse in children with phenylketonuria than in practically healthy children.
Conclusions. A complex of individualized preventive measures aimed at the increase of the enamel caries resistance and the improvement of the condition of periodontal tissues is needed for children with phenylketonuria, which should be started at their pre-school age.
Key words: dental caries, saliva, pH, buffer capacity, immunoglobulins, phenylketonuria.


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Information about authors:
Shakavets N.V. – Doctor of Medical Sciences, professor of the Chair of Pediatric Dentistry, Belarusian State Medical University;
Likhorad Y.V. – lecturer of the Chair of the Chair of Pediatric Dentistry, Belarusian State Medical University;
Zhernasek N.A. – Candidate of Biological Sciences, head of the Clinical and Diagnostic Laboratory, Joint Venture «NORDIN» Ltd. Medical Center;
Shabunya Р.S. – Candidate of Biological Sciences, leading research officer of the Physical and Chemical Research Methods Laboratory, Institute of Bioorganic Chemistry  of the Belarusian National Academy of Sciences.

Correspondence address: Republic of Belarus, 220055, Minsk, 28 Sukhaya str., Belarusian State Medical University, Chair of Pediatric Dentistry. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Yelena V. Likhorad.

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