DOI: https://doi.org/10.22263/2312-4156.2018.1.113
Myadelets O.D., Lebedeva E.I., Grushin V.N., Pilipenko N.N., Kichigina T.N., Sobolevskaya I.S., Kolmogorov V.I.
Teaching of stem cells theory at the chair of histology, cytology and embryology: regional stem cells and tissue regeneration
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2018;17(1):113-124.
Abstract.
This article is devoted to the morphofunctional properties of regional stem cells. As it is known, these are multipotent or unipotent stem cells of tissues and organs of an adult human and animal organism. They are present in small amounts in various organs and tissues and are one of the factors of tissue homeostasis. Theoretically, it is possible to consider that such cells are located in all tissues and organs of an animal organism. The article describes in detail the latest achievements in the study of regional stem cells of epithelial tissues, such as the interfollicular epidermis of the skin and the hair follicle, the stratified squamous nonkeratinized epithelium of the cornea of the eye, the simple columnar epithelium of the stomach and intestine. The structure of these stem cells niches, regulation of cells in niches are also considered in detail.
Key words: regional stem cells, epidermis, hair follicle, crypts, pericryptal myofibroblasts.
References
1. Popov BV. Introduction into cell biology of stem cells: ucheb-metod posobie. Saint-Petersburg: SpetsLit; 2010. 319 р. (In Russ.)
2. Pal'tsev MA, red. Stem cell biology and cell technology: v 2 t. Moscow, RF: Meditsina; 2009. 2 t. (In Russ.)
3. Potten CS. The epidermal proliferative unit: passible role of the central basal cell. Cell Tissue Kinet. 1974 Jan;7(1):77-88.
4. Lavker RM, San TТ. Heterogenity in epidermal basal keratinocytes: morphological and functional correlation. Science. 1982 Mar;215(4537):1239-41.
5. Lavker RM, San TТ. Epidermal stem sells. J Invest Dermatol. 1983 Jul;81(1):S121-7. doi: http://dx.doi.org/10.1111/1523-1747.ep12540880
6. Sokolov VE, Skurat LN, Stepanova LV, Sumina EB, Shayuadash SA. A study guide to the skin of mammals. Moscow, RF: Nauka; 1988. 280 р. (In Russ.)
7. Aruin LI. Stomach. V: Sarkisov DS, red. Strukturnye osnovy adaptatsii i kompen-satsii narushennykh funktsii: rukovodstvo. Moscow, RF: Meditsina; 1987. Р. 196-220. (In Russ.)
8. Aruin LI. The small intestine. V: Sarkisov DS, red. Strukturnye osnovy adaptatsii i kompensatsii narushennykh funktsii: rukovodstvo. Moscow, RF: Meditsina; 1987. Р. 220-4. (In Russ.)
9. Aruin LI. Large intestine. V: Sarkisov DS, red. Strukturnye osnovy adaptatsii i kom-pensatsii narushennykh funktsii: rukovodstvo. Moscow, RF: Meditsina; 1987. Р. 225-48. (In Russ.)
10. Barinov EF, Sulaeva ON. Gastrointestinal myofibroblast – role in the regulation of physiological activity and reparation of gastro-intestinal tract. Ros Zhurn Gastroenterologii Gepatologii Koloproktologii. 2010;20(3):9–18. (In Russ.)
11. Basson MD. Gut mucosal healing: is the science relevant? Am J Pathol. 2002 Oct;161(4):1101-5. doi: http://dx.doi.org/10.1016/S0002-9440(10)64385-4
Information about authors:
Myadelets O.D. – Doctor of Medical Sciences, professor, head of the Chair of Histology, Cytology & Embryology, Vitebsk State Order of Peoples’ Friendship Medical University;
Lebedeva E.I. – Candidate of Biological Sciences, associate professor of the Chair of Histology, Cytology & Embryology, Vitebsk State Order of Peoples’ Friendship Medical University;
Grushin V.N. – Candidate of Veterinary Sciences, associate professor of the Chair of Histology, Cytology & Embryology, Vitebsk State Order of Peoples’ Friendship Medical University;
Kichigina T.N. – Candidate of Biological Sciences, associate professor of the Chair of Histology, Cytology & Embryology, Vitebsk State Order of Peoples’ Friendship Medical University;
Sobolevskaya I.S. – Candidate of Biological Sciences, associate professor of the Chair of Histology, Cytology & Embryology, Vitebsk State Order of Peoples’ Friendship Medical University;
Pilipenko N.N. – senior lecturer of the Chair of Histology, Cytology & Embryology, Vitebsk State Order of Peoples’ Friendship Medical University;
Kolmogorov V.I. – senior lecturer of the Chair of Histology, Cytology & Embryology, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210023, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Histology, Cytology & Embryology. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Elena I. Lebedeva.
