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Talako T.M., Soroka N.F.
Correction of vitamin D deficiency in patients with suspected and verified antiphospholipid syndrome
Belarusian State Medical University, Minsk, Republic of Belarus

Vestnik VGMU. 2018;17(1):59-67.

Objectives. To study the effect of vitamin D supplementation on the content of total vitamin D and the level of antiphospholipid antibodies (APLA) in the blood of APLA-positive patients with probable and verified antiphospholipid syndrome (APS) with initial hypovitaminosis D.
Material and methods. 58 patients with APS were examined. Patients with diagnosed vitamin D hypovitaminosis were selected for further observation and investigation of the effect of cholecalciferol on the level of APLA: 21 patients with verified APS and 9 patients with probable APS. The blood levels of antibodies to cardiolipin and β2-glycoprotein I (anti-β2-GP I) were determined by ELISA test, the content of total vitamin D (25(OH)D) – by chemiluminescence method.
Results. It was found that the addition of cholecalciferol at a dose of 500-1500 IU/day during 6 months leads to a significant increase in the mean level of 25(OH)D in the blood: before treatment – 15,27 (12,56-17,45) ng/ml, after treatment – 28,60 (22,46-36,10) ng/ml (Z=4,66, p=0,001) and an increase in the proportion of patients with the level of 25(OH)D ≥ 20 ng/ml (χ2McN=16,41, p=0,001). After vitamin D supplementation a significant reduction in the level of anti-β2-GP I antibodies of IgG class was revealed (Z=2,39; p=0,017).
Conclusions. The administration of cholecalciferol in addition to the traditional treatment of APS leads to an increase in the level of 25(OH)D in the blood and a decrease in the level of anti-β2-GP I antibodies of IgG class and is pathogenetically justified in APLA-positive patients.
Key words: cholecalciferol, antiphospholipid syndrome, antibodies to β2-glycoprotein I, vitamin D.


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Information about authors:
Talako T.M. – postgraduate of the Chair of Internal Medicine No.2, Belarusian State Medical University;
Soroka N.F. – Doctor of Medical Sciences, professor, head of the Chair of Internal Medicine No.2, Belarusian State Medical University.

Correspondence address: Republic of Belarus, 220116, Minsk, 83 Dzerzhinskogo ave., Belarusian State Medical University, Chair of Internal Medicine No.2. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Nikolay F. Soroka.


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