DOI: https://doi.org/10.22263/2312-4156.2018.2.30
Bon L.I., Maksimovich N.Ye.
Morphological notions of the rat’s brain blood circulation
Grodno State Medical University, Grodno, Republic of Belarus
Vestnik VGMU. 2018;17(2):30-36.
Abstract.
Introduction. The rat is one of the widely used objects of experimental researches for studying pathology of the cerebral circulation and its influence on the morphofunctional features of the cerebral cortex.
Objectives. In order to extrapolate the data obtained in the experiment to humans, an understanding of the peculiarities of cerebral circulation in the rat is necessary.
Rat’s brain blood circulation. The blood supply to the brain of the rat includes the inflow of blood through internal carotid arteries and vertebral arteries. The circle of Willis in rats is analogous to the arterial circle of the human cerebrum.
The connection of angioarchitectonics with cerebral cytoarchitectonics. The presence of a modular organization of neurons of the cerebral cortex is connected with a similar structure of vascular networks, since the formation of the latter depends on the organization of neuronal ensembles.
Conclusions. The information presented in the article about the considerable similarity of the sources of the Willis circle formation and its topography in rats and humans, as well as the comparable anatomical structure, vessels morphometric parameters and the organization of the cerebral circulation of the rat indicate the possibility of using rats for modelling various pathologies of the cerebrovascular origin and subsequent extrapolation of the results to humans.
Key words: blood circulation, neurons, brain.
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Information about authors:
Bon L.I. – lecturer of the Chair of Pathological Physiology named after D.A. Maslakov, Grodno State Medical University;
Maksimovich N.Ye. – Doctor of Medical Sciences, professor, head of the Chair of Pathological Physiology named after D.A. Maslakov, Grodno State Medical University.
Correspondence address: Republic of Belarus, 230009, Grodno, 80, Gorky str., Grodno State Medical University, Chair of Pathological Physiology named after D.A. Maslakov. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Lizaveta I. Bon.
