DOI: https://doi.org/10.22263/2312-4156.2018.3.25
Dmitrachenko T.I., Harbachou V.U., Semenov V.M., Ziankova S.K., Shpigun N.V.
Reactivation of cytomegalovirus infection in patients being in critical state
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2018;17(3):25-37.
Abstract.
Cytomegalovirus is characterized by the all-around spread, the infection rate of the adult population reaches up to 90%. After the primary infection with this virus its lifelong latency in the host is established combined with the risk of intermittent reactivation. Cytomegalovirus reactivation is classically associated with immunosuppression, however, according to the data of recent studies, cytomegalovirus infection is more and more often detected in immunocompetent patients whose state is critical. At the same time the role of cytomegalovirus infection reactivation and its contribution to the outcome of the disease in this category of patients as well as the diagnostic criteria have not been precisely determined yet. The article presents the review of literature data on the cytomegalovirus structure, its interaction with the immune system, the reactivation of cytomegalovirus in immunocompetent patients whose state is critical.
Key words: cytomegalovirus, reactivation, immunocompetence, critical state, infection.
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Information about authors:
Dmitrachenko T.I. – Doctor of Medical Sciences, professor of the Chair of Infectious Diseases with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
Harbachou V.U. – MSc (Medicine) student of the Chair of Infectious Diseases with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
Semenov V.M. – Doctor of Medical Sciences, professor, head of the Chair of Infectious Diseases with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
Ziankova S.K. – Candidate of Medical Sciences, associative professor of the Chair of Infectious Diseases with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
Shpigun N.V. – lecturer of the Chair of Infectious Diseases with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210023, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Infectious Diseases with the course of the Faculty for Advanced Training & Retraining. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Tatyana I. Dmitrachenko.
