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DOI: https://doi.org/10.22263/2312-4156.2018.3.67

Shmak A.I., Erzinkiani F.V., Martynau Y.P., Kotаu A.A., Yarashenka H.V.
Epidemiological peculiarities of malignant neoplasms of the hepatopancreatobiliary zone in the world and in the Republic of Belarus
N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Republic of Belarus

Vestnik VGMU. 2018;17(3):67-75.

Abstract.
Malignant neoplasms of the hepatopancreatobiliary zone (HPBZ) are complex and unresolved sections in clinical oncology. Population rates of morbidity and mortality almost coincide in all countries of the world.
The article presents a statistical analysis of the epidemiological data on morbidity, mortality and cumulative survival of patients suffering from pancreatic cancer (PC), primary liver cancer (PLC) and gallbladder cancer (GC). Over the past 20 years, the annual morbidity rate has increased by 2% for PC, 1,7% for PLC, and 2,6% for GC, respectively. As to mortality rates from 1997 to 2017 they made up 2,4% for PC, 1% for PLC, 1% for GC, respectively. The best indices of the 5-year cumulative adjusted survival of patients with PC, PLC and GC from 2002 to 2016 amounted at the I-II stage to 52.8%, 87,7% and 58,8%, respectively. In case of locally prevalent and metastatic stages of the diseases 5-year cumulative survival rate for the last 20 years has practically not changed for any of the above-mentioned oncopathologies.
Malignant tumors of the GPBZ are biologically aggressive and as a result lead to early generalization of the tumor process and unsatisfactory results of treatment. Thus, the relevance of malignant tumors of the GPBZ problem in the world and in the Republic of Belarus is beyond doubt. Constantly increasing trends in morbidity and mortality rates against the background of unresolved issues of early diagnosis and lack of effective methods of treatment require today and in the future the efforts of the medical community.
Key words: epidemiology of pancreatic cancer, primary liver cancer, gallbladder cancer, diseases, mortality in the world and the Republic of Belarus.

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Information about authors:
Shmak A.I. – Doctor of Medical Sciences, head of the Laboratory of Abdominal Oncopathology, N.N. Alexandrov National Cancer Center of Belarus;
Erzinkiani F.V. – associate research officer of the Laboratory of Abdominal Oncopathology, N.N. Alexandrov National Cancer Center of Belarus;
Martynau Y.P. – associate research officer of the Laboratory of Abdominal Oncopathology, N.N. Alexandrov National Cancer Center of Belarus;
Kotau A.A. – head of the department of hepatopancreatobiliary pathology, oncologist-surgeon, N.N. Alexandrov National Cancer Center of Belarus;
Yarashenka H.V. – oncologist-surgeon of the department of hepatopancreatobiliary pathology, N.N. Alexandrov National Cancer Center of Belarus.

Correspondence address: Republic of Belarus, 223040, Minsk district, agrogorodok Lesnoy, N.N. Alexandrov National Cancer Centre of Belarus, Laboratory of Abdominal Oncopathology. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Felix V. Erzinkiani.

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