DOI: https://doi.org/10.22263/2312-4156.2018.4.22
Bon L.I., Maksimovich N.Ye.
Methods of neurological disorders estimation in an experiment
Grodno State Medical University, Grodno, Republic of Belarus
Vestnik VGMU. 2018;17(4):22-28.
Abstract.
Introduction. The rat is an important object of experimental studies, including those that investigate the cerebral cortex in the norm and in different pathologies. The study of the pathology of the brain in the experiment necessitates adequate methods of assessing the neurological deficit that occurs in animals, including sensorimotor and behavioral disorders, as well as disorders of higher nervous activity.
Objectives. To summarize literature data on possible ways of assessing sensory-motor reflexes, learning and memory in experimental animals at different ages.
Conclusions. There is a wide range of methods for evaluating neurological disorders in laboratory animals, which allows us to study the level of neurological deficits development in various pathologies of the nervous system, cerebral ischemia included, as well as to study the disorders of brain maturation in postnatal ontogenesis on modelling embryo- and fetopathy and testing methods for their correction.
Key words: brain, neurological deficit, rats.
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Information about authors:
Bon L.I. – lecturer of the Chair of Pathological Physiology named after D.A. Maslakov, Grodno State Medical University;
Maksimovich N.Ye. – Doctor of Medical Sciences, professor, head of the Chair of Pathological Physiology named after D.A. Maslakov, Grodno State Medical University.
Correspondence address: Republic of Belarus, 230009, Grodno, 80, Gorky str., Grodno State Medical University, Chair of Pathological Physiology named after D.A. Maslakov. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Lizaveta I. Bon.
