DOI: https://doi.org/10.22263/2312-4156.2018.4.29
Polukhova Sh.M., Musayeva E.M., Huseinova G.A., Kasymova S.V., Jafarova R.A.
Drug-induced hepatopathies
Azerbaijan Medical University, Baku, Azerbaijan
Vestnik VGMU. 2018;17(4):29-36.
Abstract.
The review of the available literature shows that the prevalence of hepatopathies is increasing year after year in the whole world. Practically all drugs that are metabolized in the liver are hepatotoxic. The probability of the liver failure depends both on physical and chemical properties of drugs and patient’s individual characteristics, including the genetic ones. Hepatotoxicity of drugs increases in case of repeated administration and when a combination of several drugs is taken. Hepatotoxicity of various medications develops according to different scenarios of pathogenetic mechanisms and may possess morphologically individual features. Depending on individual characteristics of the human body one and the same drug can trigger distinct pathology development mechanisms with different morphological features, for all this hepatotoxicity of the medications representing totally different groups can develop in the same way.
Key words: liver, drugs, toxicity, ethiopathogenetical mechanisms.
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Information about authors:
Polukhova Sh.M. – Candidate of Biological Sciences, senior research officer of the Chair of Pharmacology, Azerbaijan Medical University;
Musayeva E.M. – Candidate of Biological Sciences, lecturer of the Chair of Pharmacology, Azerbaijan Medical University;
Huseinova G.A. – Candidate of Medical Sciences, associate professor of the Chair of Pharmacology, Azerbaijan Medical University;
Kasymova S.V. – senior laboratory assistant of the Chair of Family Medicine, Azerbaijan Medical University;
Jafarova R.A. – Doctor of Biological Sciences, head of the Department of Toxicology of the Scientific Research Center, Azerbaijan Medical University.
Correspondence address: Azerbaijan, AZ1022, Baku, 23 Bakikhanov str., Azerbaijan Medical University, Scientific Research Center, Department of Toxicology. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Rana A. Jafarova.
